{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T11:06:33Z","timestamp":1649070393678},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:00:00Z","timestamp":1522281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n            Introduction\u2003Intraoperative parathyroid hormone (ioPTH) testing is a widely accepted standard for assessing the parathyroid gland function. A decline of preoperative parathyroid hormone (PTH) levels by more than 50% is one accepted measure of parathyroid surgery adequacy. However, there may be a variation between preoperative PTH levels obtained at a clinic visit and pre-excisional ioPTH.<\/jats:p><jats:p>\n            Objective\u2003Our study explores the differences between preoperative PTH and pre-excisional ioPTH levels, and the potential impact this difference has on determining the adequacy of parathyroid surgery.<\/jats:p><jats:p>\n            Methods\u2003A retrospective study that consisted of 33 patients that had undergone parathyroid resection between September 2009 and March 2016 at a tertiary academic center was performed. Each subject's preoperative PTH levels were obtained from clinic visits and pre-excisional ioPTH levels were recorded along with the time interval between the measurements.<\/jats:p><jats:p>\n            Results\u2003There was a significant difference between the mean preoperative PTH and the pre-excisional ioPTH levels of 147 pg\/mL (95% confidence interval [CI] 11.43 to 284.47; p\u2009=\u20090.0396). The exclusion of four outliers revealed a further significant difference with a mean of 35.09 pg\/mL (95% CI 20.27 to 49.92; p\u2009&lt;\u20090.0001). The average time interval between blood draws was 48 days\u2009+\u200932 days. A weak correlation between the change in PTH values and the time interval between preoperative and pre-excision blood draws was noted (r2\u2009=\u20090.15).<\/jats:p><jats:p>\n            Conclusion\u2003Our study reveals a significant difference between the preoperative PTH levels obtained at clinic visits and the pre-excisional intraoperative PTH levels. We recommend routine pre-excisional intraoperative PTH levels, despite evidence of elevated preoperative PTH levels, in order to more accurately assess the adequacy of surgical resection.<\/jats:p>","DOI":"10.1055\/s-0038-1635574","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T22:52:07Z","timestamp":1522363927000},"page":"382-386","source":"Crossref","is-referenced-by-count":0,"title":["Disparity between Preoperative and Pre-Excisional Intraoperative Parathyroid Hormone in Parathyroid Surgery"],"prefix":"10.1055","volume":"22","author":[{"given":"Maheer","family":"Masood","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Hackman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,3,29]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1635574.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T21:10:56Z","timestamp":1557177056000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1635574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,29]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,10,22]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1635574","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,29]]}}}