{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:42:38Z","timestamp":1792078958034,"version":"4.4.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>\n            Background\u2003Paravalvular aortic regurgitation (PVAR) remains a frequent postprocedural concern following transcatheter aortic valve replacement (TAVR). Persistence of flow turbulence results in the cleavage of high-molecular-weight von Willebrand multimers, primary haemostasis dysfunction and may favour bleedings. Recent data have emphasized the value of a point-of-care measure of von Willebrand factor\u2013dependent platelet function (closure time [CT] adenosine diphosphate [ADP]) in the monitoring of immediate PVAR. This study examined whether CT-ADP could detect PVAR at 30 days and bleeding complications following TAVR.<\/jats:p><jats:p>\n            Methods\u2003CT-ADP was assessed at baseline and the day after the procedure. At 30 days, significant PVAR was defined as a circumferential extent of regurgitation more than 10% by transthoracic echocardiography. Events at follow-up were assessed according to the Valve Academic Research Consortium-2 consensus classification.<\/jats:p><jats:p>\n            Results\u2003Significant PVAR was diagnosed in 44 out of 219 patients (20.1%). Important reduction of CT-ADP could be found in patients without PVAR, contrasting with the lack of CT-ADP improvement in significant PVAR patients. By multivariate analysis, CT-ADP\u2009&gt;\u2009180\u2009seconds (hazard ratio [HR]: 5.1, 95% confidence interval [CI]: 2.5\u201310.6; p\u2009&lt;\u20090.001) and a self-expandable valve were the sole independent predictors of 30-day PVAR. At follow-up, postprocedural CT-ADP &gt;180\u2009seconds was identified as an independent predictor of major\/life-threatening bleeding (HR: 1.7, 95% CI [1.0\u20133.1]; p\u2009=\u20090.049). Major\/life-threatening bleedings were at their highest levels in patients with postprocedural CT-ADP\u2009&gt;\u2009180\u2009seconds (35.2 vs. 18.8%; p\u2009=\u20090.013).<\/jats:p><jats:p>\n            Conclusion\u2003Postprocedural CT-ADP\u2009&gt;\u2009180\u2009seconds is an independent predictor of significant PVAR 30 days after TAVR and may independently contribute to major\/life-threatening bleedings.<\/jats:p>","DOI":"10.1055\/s-0038-1639352","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T23:44:14Z","timestamp":1522280654000},"page":"893-905","source":"Crossref","is-referenced-by-count":24,"title":["CT-ADP Point-of-Care Assay Predicts 30-Day Paravalvular Aortic Regurgitation and Bleeding Events following Transcatheter Aortic Valve Replacement"],"prefix":"10.1055","volume":"118","author":[{"given":"Marion","family":"Kibler","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Marchandot","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Messas","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Caspar","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavien","family":"Vincent","sequence":"first","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier Universitaire Lille, Lille, France"},{"name":"Universitaire Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Von Hunolstein","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lelia","family":"Grunebaum","sequence":"first","affiliation":[{"name":"Department of Haemostasis, Centre Hospitalier Universitaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Reydel","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Rauch","sequence":"first","affiliation":[{"name":"Universitaire Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulun","family":"Crimizade","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Kindo","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam","family":"Hoang Minh","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Trinh","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Petit-Eisenmann","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"De Poli","sequence":"first","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier de Haguenau, Haguenau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Leddet","sequence":"first","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier de Haguenau, Haguenau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jesel","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"},{"name":"UMR INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ohlmann","sequence":"first","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Susen","sequence":"first","affiliation":[{"name":"Universitaire Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Van Belle","sequence":"first","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier Universitaire Lille, Lille, France"},{"name":"Universitaire Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Morel","sequence":"additional","affiliation":[{"name":"P\u00f4le d'Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, Universit\u00e9 de Strasbourg, Strasbourg, France"},{"name":"UMR INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,3,28]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1639352.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T22:31:22Z","timestamp":1527719482000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1639352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,28]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2018,5,30]]},"published-print":{"date-parts":[[2018,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1639352","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,28]]}}}