{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T19:40:07Z","timestamp":1721331607286},"reference-count":24,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"03","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n            Objective\u2003To assess the management chosen by gynecologists after atypical squamous cells (ASCs) cytology results, and to evaluate the outcomes of these cases in Brazilian women.<\/jats:p><jats:p>\n            Methods\u2003A prospective observational study evaluated the initial management offered by the gynecologist in the case of 2,458 ASCs cytology results collected between January of 2010 and July of 2016. The outcomes of the cytology, high-risk human papilloma virus (HR-HPV) test and histology were compared in two subgroups: atypical squamous cells of undetermined significance (ASC-US) and atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H).<\/jats:p><jats:p>\n            Results\u2003In many cases of ASC-US (36.97%) and ASC-H (40.50%), no clinical actions were taken. Cytology was the most frequent follow-up chosen, including for cases of ASC-H, which goes against the conduct recommended in the national guideline. In women over 30 years of age, the period of time elapsed between an ASC-US result and a new cytology was in 13.03 months, in disagreement with the national guideline recommendations (p\u2009&lt;\u20090.0001). Negative for intraepithelial lesions or malignancy (NILM) cytologic (p\u2009=\u20090.0026) and histologic (p\u2009=\u20090.0017) results in the follow-up were associated with prior ASC-US, while negative results for ASC-H were cytologically (p\u2009&lt;\u20090.0001) and histologically associated with high-grade squamous intraepithelial lesion (HSIL) (p\u2009&lt;\u20090.0001). Two invasive cervical carcinomas (ICCs) were found in the follow-up for ASC-H, and there was a statistically significant association (p\u2009=\u20090.0341). A positive HR-HPV test was associated with ASC-H (p\u2009=\u20090.0075).<\/jats:p><jats:p>\n            Conclusion\u2003The data suggest that even for a population of Brazilian women assisted at private clinics, the national guidelines recommendations for ASCs results are not followed.<\/jats:p>","DOI":"10.1055\/s-0038-1639466","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T23:51:31Z","timestamp":1521503491000},"page":"121-126","source":"Crossref","is-referenced-by-count":2,"title":["Management of Atypical Squamous Cell Cases: A Prospective Study of Women seen at a Private Health Service in Northeastern Brazil"],"prefix":"10.61622","volume":"40","author":[{"given":"Geilson Gomes de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Federal do Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judite Maria da Silva Costa de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Federal do Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Mirian Nunes","family":"Eleut\u00e9rio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Universidade Federal do Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Eleut\u00e9rio J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Federal do Cear\u00e1, Fortaleza, Brazil"},{"name":"Department of Motherhood and Child, Universidade Federal do Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijgo.2014.01.020","article-title":"Distribution of various types of low-risk human papillomavirus according to cervical cytology and histology in northern Chinese women","volume":"126","author":"H Wei","year":"2014","journal-title":"Int J Gynaecol Obstet"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7314\/APJCP.2013.14.1.511","article-title":"Cost and effectiveness comparison of immediate colposcopy versus human papillomavirus DNA testing in management of atypical squamous cells of undetermined significance in Turkish women","volume":"14","author":"M Kececioglu","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"e0127444","DOI":"10.1371\/journal.pone.0127444","article-title":"minor cytological abnormalities and up to 7-year risk for subsequent high-grade lesions by HPV type","volume":"10","author":"M Persson","year":"2015","journal-title":"PLoS One"},{"issue":"03","key":"ref4","first-page":"CD008054","article-title":"Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions","author":"M Arbyn","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijgo.2014.07.027","article-title":"Human papillomavirus among women with atypical squamous cells of undetermined significance in southern Brazil","volume":"128","author":"S Paesi","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"904674","DOI":"10.1155\/2011\/904674","article-title":"Atypical squamous cells of undetermined significance: Bethesda classification and association with Human Papillomavirus","volume":"2011","author":"A C Barcelos","year":"2011","journal-title":"Infect Dis Obstet Gynecol"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cncy.21661","article-title":"Triage of ASC-H: A meta-analysis of the accuracy of high-risk HPV testing and other markers to detect cervical precancer","volume":"124","author":"L Xu","year":"2016","journal-title":"Cancer Cytopathol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ygyno.2015.06.040","article-title":"A study of HPV typing for the management of HPV-positive ASC-US cervical cytologic results","volume":"138","author":"M Schiffman","year":"2015","journal-title":"Gynecol Oncol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/1516-3180.2014.9142511","article-title":"Clinical management of the first ASCUS report in Chile. 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