{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:13:34Z","timestamp":1772190814823,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"\n Background\u2003While anti-\u03b22 glycoprotein 1 (anti-\u03b22GP1) antibody positivity is included in the diagnostic criteria for antiphospholipid syndrome (APS), the association between anti-\u03b22GP1 and the obstetrical complications of APS has been inconsistently reported and remains unclear.<\/jats:p>\n Objective\u2003We completed a case\u2013control study nested within the Canadian Ottawa and Kingston (OaK) Birth Cohort to evaluate the association between anti-\u03b22GP1 antibody positivity and placenta-mediated pregnancy complications.<\/jats:p>\n Study Design\u2003Five hundred cases were randomly selected among pregnant women who experienced any of the following independently adjudicated placenta-mediated pregnancy complications: preeclampsia, placental abruption, late pregnancy loss (\u2265 12 weeks' gestation), and birth of a small-for-gestational age (SGA) infant\u2009<\u200910th percentile. Five hundred pregnant women without any placenta-mediated pregnancy complications were selected as controls. Stored blood samples were analyzed for the presence of anti-\u03b22GP1 antibodies by enzyme-linked immunosorbent assay.<\/jats:p>\n Results\u2003Anti-\u03b22GP1 immunoglobulin G (IgG) and\/or immunoglobulin M (IgM) antibodies in titers\u2009\u2265\u200920 G\/M units (> 99th percentile) were present in 24 of 497 (4.8%) of controls and 33 of 503 (6.6%) of cases. There was no significant difference between cases and controls for the composite outcome of any placenta-mediated pregnancy complications (odds ratio, 1.38, 95% confidence interval [CI], 0.8\u20132.37, p\u2009=\u20090.25).<\/jats:p>\n Conclusion\u2003Our results call into question the association between anti-\u03b22GP1 antibodies and placenta-mediated pregnancy complications, with further research needed.<\/jats:p>","DOI":"10.1055\/s-0038-1641168","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T22:41:50Z","timestamp":1523400110000},"page":"1093-1099","source":"Crossref","is-referenced-by-count":6,"title":["Are Anti-\u03b22 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case\u2013Control Study"],"prefix":"10.1055","volume":"35","author":[{"given":"Leslie","family":"Skeith","sequence":"first","affiliation":[{"name":"Division of Hematology and Hematological Malignancies, Department of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Abou-Nassar","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie et Axe de Recherche en Canc\u00e9rologie, Centre Int\u00e9gr\u00e9 de Sant\u00e9 et de Services Sociaux de l'Outaouais, Gatineau, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Walker","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Ramsay","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Booth","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Wen","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Smith","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Rodger","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,4,10]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1641168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T22:40:18Z","timestamp":1535755218000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1641168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,8,31]]},"published-print":{"date-parts":[[2018,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1641168","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]}}}