{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:37:56Z","timestamp":1757705876612},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            Objective\u2003To evaluate how duration of exposure to antenatal corticosteroids (ACSs) prior to delivery affects neonatal outcomes in indicated preterm deliveries.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort of all indicated singleton preterm deliveries (23\u201334 weeks) in a single tertiary center from 2011 to 2014 comparing those who received ACS 2 to 7 days versus &gt;7 days prior to delivery. The primary neonatal outcome was a composite of arterial cord pH\u2009&lt;\u20097 or base excess \u2264 12, 5-minute Apgar\u2009\u2264\u20093, cardiopulmonary resuscitation, culture-proven neonatal sepsis, intraventricular hemorrhage grade III\/IV, necrotizing enterocolitis, and neonatal death. Analyses were stratified by delivering gestational age (230\/7\u2013276\/7, 280\/7\u2013316\/7, and 320\/7\u2013336\/7 weeks). Multivariate logistic regression refined point estimates and adjusted for confounders.<\/jats:p><jats:p>\n            Results\u2003In total, 301 women delivered &gt;48 hours after initial ACS dose, 230 delivered within 2 to 7 days, and 71 delivered &gt;7 days. Infants with an interval of &gt;7 days had no significant increase in the unadjusted composite neonatal outcome (p\u2009=\u20090.42), but when adjusted, the composite neonatal outcome (adjusted odds ratio [AOR]: 2.7; 95% confidence interval [CI]: 1.18\u20136.31) and neonatal death (AOR: 4.20; 95% CI: 1.39\u201312.69) were significantly increased with an ACS interval of &gt;7 day.<\/jats:p><jats:p>\n            Conclusion\u2003In this cohort, the benefit of ACS diminished &gt;7 days after administration, particularly when delivery occurred at &lt;32 weeks.<\/jats:p>","DOI":"10.1055\/s-0038-1646955","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T22:47:15Z","timestamp":1524869235000},"page":"039-044","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal Outcomes Based on Duration of Exposure to Antenatal Corticosteroids in Indicated Preterm Deliveries"],"prefix":"10.1055","volume":"36","author":[{"given":"Spencer","family":"Kuper","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Dimperio","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Tita","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Biggio","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorie","family":"Harper","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase","family":"Cawyer","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,4,27]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1646955.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T09:24:50Z","timestamp":1547803490000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1646955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,27]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,1,9]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1646955","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,27]]}}}