{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:21:19Z","timestamp":1792678879947,"version":"4.5.0"},"reference-count":19,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"05","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>\n            Objective\u2003To assess the cost-effectiveness of carbetocin versus oxytocin for prevention of postpartum hemorrhage (PPH) due to uterine atony after vaginal delivery\/cesarean section in women with risk factors for bleeding.<\/jats:p><jats:p>\n            Methods\u2003A decision tree was developed for vaginal delivery and another one for cesarean, in which a sequential analysis of the results was obtained with the use of carbetocin and oxytocin for prevention of PPH and related consequences. A third-party payer perspective was used; only direct medical costs were considered. Incremental costs and effectiveness in terms of quality-adjusted life years (QALYs) were evaluated for a one-year time horizon. The costs were expressed in 2016 Colombian pesos (1 USD\u2009=\u20093,051 Col$).<\/jats:p><jats:p>\n            Results\u2003In the vaginal delivery model, the average cost of care for a patient receiving prophylaxis with uterotonic agents was Col$ 347,750 with carbetocin and Col$ 262,491 with oxytocin, while the QALYs were 0.9980 and 0.9979, respectively. The incremental cost-effectiveness ratio is above the cost-effectiveness threshold adopted by Colombia. In the model developed for cesarean section, the average cost of a patient receiving prophylaxis with uterotonics was Col$ 461,750 with carbetocin, and Col$ 481,866 with oxytocin, and the QALYs were 0.9959 and 0.9926, respectively. Carbetocin has lower cost and is more effective, with a saving of Col$ 94,887 per avoided hemorrhagic event.<\/jats:p><jats:p>\n            Conclusion\u2003In case of elective cesarean delivery, carbetocin is a dominant alternative in the prevention of PPH compared with oxytocin; however, it presents higher costs than oxytocin, with similar effectiveness, in cases of vaginal delivery.<\/jats:p>","DOI":"10.1055\/s-0038-1655747","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T22:59:41Z","timestamp":1529362781000},"page":"242-250","source":"Crossref","is-referenced-by-count":13,"title":["Cost-effectiveness of Carbetocin versus Oxytocin for Prevention of Postpartum Hemorrhage Resulting from Uterine Atony in Women at high-risk for bleeding in Colombia"],"prefix":"10.61622","volume":"40","author":[{"given":"Yaneth","family":"Gil-Rojas","sequence":"additional","affiliation":[{"name":"NeuroEconomix, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieralessandro","family":"Lasalvia","sequence":"additional","affiliation":[{"name":"NeuroEconomix, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"NeuroEconomix, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Casta\u00f1eda-Cardona","sequence":"additional","affiliation":[{"name":"NeuroEconomix, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Rosselli","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Facultad de Medicina de la Pontificia Universidad Javeriana, Bogota, 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