{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T04:02:34Z","timestamp":1751774554451,"version":"3.41.0"},"reference-count":17,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"07","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polyglandular autoimmune syndrome type II (PGA-II) is a rare immunoendocrinopathy syndrome characterized by the occurrence of autoimmune Addison disease along with diabetes mellitus type 1 and\/or autoimmune thyroid disease. Here, we report the case of a 23-year-old female with PGA-II who was followed up at the dermatology and endocrinology clinics of the Universidade Federal do Tri\u00e2ngulo Mineiro, located in the state of Minas Gerais, Brazil. First, the patient presented diffuse skin hyperpigmentation, vitiligo; and in sequence, due to vomiting, appetite and weight loss, hypoglycemia, amenorrhea, and galactorrhea, the patient was then diagnosed with PGA-II. The patient also presented intense hyperprolactinemia due to primary hypothyroidism. The late diagnosis of PGA-II is frequent because the disorder is uncommon and has non-specific clinical manifestations. This report emphasizes the significance of a timely diagnosis and appropriate treatment to reduce morbidity and mortality associated with these diseases, especially Addison disease. The present study reports a rare case of a patient with PGA-II with primary amenorrhea associated with hyperprolactinemia.<\/jats:p>","DOI":"10.1055\/s-0038-1655749","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T23:39:01Z","timestamp":1530142741000},"page":"425-429","source":"Crossref","is-referenced-by-count":1,"title":["Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report"],"prefix":"10.61622","volume":"40","author":[{"given":"Luiza Tizziotti","family":"Cottas","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia Prata Santos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lu\u00edsa Mantovani","family":"Resende","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meire Soares","family":"Ata\u00edde","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete Aparecida Mantovani Rodrigues","family":"Resende","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"ref1","first-page":"69","article-title":"S\u00edndrome poliglandular autoimune tipo 2: caracteriza\u00e7\u00e3o cl\u00ednico-laboratorial e recomenda\u00e7\u00f5es de abordagem e seguimento","volume":"5","author":"S Gouveia","year":"2010","journal-title":"Rev Port Endocrinol Metab"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/09513590.2015.1137096","article-title":"Latent polyglandular autoimmune syndrome type 2 case diagnosed during a shock manifestation","volume":"32","author":"E G\u00fcrkan","year":"2016","journal-title":"Gynecol Endocrinol"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1590\/S0004-27302013000900010","article-title":"Rastreio de s\u00edndrome poliglandular autoimune em uma popula\u00e7\u00e3o de pacientes com diabetes melito tipo 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