{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:08:48Z","timestamp":1772813328120,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n            Background\u2003Acute encephalitis syndrome (AES) is endemic to certain parts of India, with limited treatment options. In our initial exploratory comparative observational study of 151 patients with AES, there was significantly reduced mortality with adjunctive homeopathy compared to institutional management protocol (IMP). The present randomized placebo-controlled trial brings more statistical rigor to this research program.<\/jats:p><jats:p>\n            Methods\u2003This study was conducted at a pediatric unit from 2013 to 2015. Children aged\u2009&gt;\u20096 months and\u2009\u2264\u200918 years and receiving IMP were randomized to receive adjunctive homeopathy (n\u2009=\u2009325) or placebo as control (n\u2009=\u2009323). The primary effectiveness analysis was based on Glasgow Outcome Scale (GOS). Morbidity was assessed using the Liverpool Outcome Score for Assessing Children at Follow-up. Analysis was by intention to treat.<\/jats:p><jats:p>\n            Results\u2003A total of 612 children were analyzed (Homeopathy [H]\u2009=\u2009304; Control [C] =\u2009308). The primary outcome, GOS, differed significantly between H and C groups. There was 14.8% death\/neuro-vegetative state in the H group compared to 29.8% in the C group. Relative risk was 0.49 (95% confidence interval [CI]: 0.36 to 0.68), with absolute risk reduction of 15.0% (95% CI: 8.6 to 21.6%). Number needed to treat to prevent one additional death\/neuro-vegetative state was 6.6 (95% CI: 4.6 to 11.6). Proportional-odds analysis also revealed a greater effect in the H group: odds ratio, 0.40 (95% CI: 0.27 to 0.60). The most frequently used medicines were Belladonna (n\u2009=\u2009116), Stramonium (n\u2009=\u200933), Arsenicum album (n\u2009=\u200925), Sulfur (n\u2009=\u200918), Opium (n\u2009=\u200917), and Nux vomica (n\u2009=\u200910).<\/jats:p><jats:p>\n            Conclusion\u2003Adjunctive homeopathic medicines may improve clinical outcomes associated with AES. Further randomized and controlled studies, using double-blinded trial design, are recommended to discover if the current findings may be corroborated.<\/jats:p>","DOI":"10.1055\/s-0038-1656715","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T18:54:06Z","timestamp":1528224846000},"page":"161-171","source":"Crossref","is-referenced-by-count":23,"title":["Effectiveness of Homeopathic Medicines as Add-on to Institutional Management Protocol for Acute Encephalitis Syndrome in Children: An Open-Label Randomized Placebo-Controlled Trial"],"prefix":"10.1055","volume":"107","author":[{"given":"Praveen","family":"Oberai","sequence":"first","affiliation":[{"name":"Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Padmanabhan","sequence":"first","affiliation":[{"name":"Former Statistical Assistant, Central Council for Research in Homeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok","family":"Upadhyaya","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Singh","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samarendra","family":"Singh","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Vikram","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Khan","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Prasad","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gupta","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Singh","sequence":"first","affiliation":[{"name":"Clinical Trial Unit(H), Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Manchanda","sequence":"first","affiliation":[{"name":"Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roja","family":"Varanasi","sequence":"additional","affiliation":[{"name":"Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,6,5]]},"container-title":["Homeopathy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1656715.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T18:34:12Z","timestamp":1533666852000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1656715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,8,7]]},"published-print":{"date-parts":[[2018,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1656715","relation":{},"ISSN":["1475-4916","1476-4245"],"issn-type":[{"value":"1475-4916","type":"print"},{"value":"1476-4245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]}}}