{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:51:44Z","timestamp":1715615504235},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-\u03b1) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (n\u2009=\u20097) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [n\u2009=\u20095], enteroviral meningitis [n\u2009=\u200910], nonspecific viral illness without central nervous system involvement [n\u2009=\u200910]). PTX3 and TNF-\u03b1 were rarely detected and only in trace concentration in KD, and the levels of IL-6 were not different from those of nonspecific viral illnesses. These mediators are not established biomarkers for cerebral vasculitis but might reflect vascular inflammation in various diseases including KD. Therefore, intracranial inflammation including vasculitis seems to be insignificant in our patients with KD. However, our results might be attributed to the fact that these patients lacked any clinical signs of cerebral or coronary vessel involvement. None of them underwent brain imaging. To clarify this issue, further studies involving patients with neurologic symptoms and proven involvement of cerebral vessels are needed.<\/jats:p>","DOI":"10.1055\/s-0038-1660855","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T19:05:11Z","timestamp":1529348711000},"page":"392-396","source":"Crossref","is-referenced-by-count":3,"title":["A Pilot Study Evaluating Cerebral Vasculitis in Kawasaki's Disease"],"prefix":"10.1055","volume":"49","author":[{"given":"Jung Sook","family":"Yeom","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hye","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Mo","family":"Koo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Su","family":"Jun","sequence":"first","affiliation":[{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sook","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sil","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Young","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Shang","family":"Youn","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang-Ok","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, Republic of Korea"},{"name":"Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,6,18]]},"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1660855.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T18:33:21Z","timestamp":1542047601000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1660855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2018,11,12]]},"published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1660855","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"value":"0174-304X","type":"print"},{"value":"1439-1899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]}}}