{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:57:47Z","timestamp":1778540267384,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n            Objective\u2003To determine independent perinatal associations of anxiety and depression in women who were and were not treated with psychotropic drugs in comparison to unaffected pregnancies.<\/jats:p><jats:p>\n            Study Design\u2003From 2013 to 2014, 978 (6.3%) cases of anxiety\/depression, of which 35% used psychotropic drugs, were compared with 14,514 (93.7%) unaffected pregnancies using logistic regression.<\/jats:p><jats:p>\n            Results\u2003Subjects were more likely to be Non-Hispanic Whites, use tobacco and illegal substances, be unmarried, use public insurance, and have medical complications of pregnancy. For independent maternal outcomes, untreated anxiety\/depression was associated with labor induction (adjusted odds ratio [aOR]\u2009=\u20092.02), cesarean deliveries (aOR\u2009=\u20091.69), longer length of stay (aOR\u2009=\u20091.96), readmission (aOR\u2009=\u20092.40), fever (aOR\u2009=\u20092.03), magnesium exposure (aOR\u2009=\u20091.82), and postpartum hemorrhage (aOR\u2009=\u20092.57), whereas treated cases were associated with increased blood transfusion (aOR\u2009=\u20094.81), severe perineal lacerations (aOR\u2009=\u20092.93), and postpartum hemorrhage (aOR\u2009=\u20093.85), but decreased risk of cesarean deliveries (aOR\u2009=\u20090.59). Independent neonatal outcomes included small for gestational age (aOR\u2009=\u20093.04), meconium-stained fluid (aOR\u2009=\u20091.85; 2.61), respiratory failure (aOR\u2009=\u20095.84), neonatal adaptation syndrome (aOR\u2009=\u200911; 10.2), and neonatal seizures (aOR\u2009=\u200912.3) in treated cases, whereas untreated cases were associated with hypoxia (aOR\u2009=\u20092.83), low Apgar score (aOR\u2009=\u20093.82), and encephalopathy (aOR\u2009=\u200918.3). Exposure to multiple psychotropic medications independently increased the risk of neonatal adaptation syndrome, neonatal length of stay, and hypoglycemia.<\/jats:p><jats:p>\n            Conclusion\u2003Untreated cases were associated with increased maternal adverse outcomes, whereas treated cases were associated with more adverse neonatal outcomes when compared with unaffected pregnancies.<\/jats:p>","DOI":"10.1055\/s-0038-1661379","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T22:44:52Z","timestamp":1531262692000},"page":"e146-e157","source":"Crossref","is-referenced-by-count":33,"title":["The Contribution of Untreated and Treated Anxiety and Depression to Prenatal, Intrapartum, and Neonatal Outcomes"],"prefix":"10.1055","volume":"08","author":[{"given":"Dotun","family":"Ogunyemi","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beaumont Hospital, Royal Oak, Michigan"},{"name":"Department of Obstetrics and Gynecology, Oakland University, William Beaumont School of Medicine, Rochester Hills, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Jovanovski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oakland University, William Beaumont School of Medicine, Rochester Hills, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beaumont Hospital, Royal Oak, Michigan"},{"name":"Department of Obstetrics and Gynecology, Oakland University, William Beaumont School of Medicine, Rochester Hills, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beaumont Hospital, Royal Oak, Michigan"},{"name":"Department of Obstetrics and Gynecology, Oakland University, William Beaumont School of Medicine, Rochester Hills, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"University of Vermont Robert Larner College of Medicine, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Creps","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oakland University, William Beaumont School of Medicine, Rochester Hills, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichchha","family":"Madan","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beaumont Hospital, Royal Oak, Michigan"},{"name":"Department of Obstetrics and Gynecology, Oakland University, William Beaumont School of Medicine, Rochester Hills, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,7,10]]},"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1661379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T20:46:56Z","timestamp":1557175616000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1661379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,7,10]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1661379","relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"value":"2157-6998","type":"print"},{"value":"2157-7005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}