{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:24:45Z","timestamp":1762917885927},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            Objective\u2003This article evaluates the differences in adverse maternal outcomes related to severe preeclampsia in obese versus nonobese women.<\/jats:p><jats:p>\n            Study Design\u2003Retrospective cohort study and planned secondary analysis of women with severe preeclampsia comparing a composite adverse maternal outcome related to preeclampsia among obese (body mass index [BMI] \u2265 30 kg\/m2) and nonobese (BMI\u2009&lt;\u200930 kg\/m2) women. The composite outcome was defined as \u2265 1 of the following prior to discharge: renal failure, liver abnormality, thrombocytopenia, blood transfusion, pulmonary edema, disseminated intravascular coagulation, stroke, or eclampsia. Multivariable logistic regression was used to control for confounders.<\/jats:p><jats:p>\n            Results\u2003Of the 152 women included, 37.5% were obese and 62.5% were nonobese. The prevalence of the primary outcome was 15.8% with obese women less likely to have the composite outcome compared with nonobese women (7% vs. 21.1%, p\u2009=\u20090.02). This remained after adjusting for confounders including maternal age, race, and chronic hypertension (adjusted odds ratio, 0.33 [0.12\u20130.89], p\u2009=\u20090.03). Obese women were, however, more likely to require intravenous antihypertensive medication peripartum compared with nonobese women (49.1% vs. 28.4%, p\u2009=\u20090.01).<\/jats:p><jats:p>\n            Conclusion\u2003Obese women with severe preeclampsia may have a different phenotype of severe preeclampsia that is more associated with severe hypertension rather than end-organ damage.<\/jats:p>","DOI":"10.1055\/s-0038-1661403","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T22:56:53Z","timestamp":1530917813000},"page":"074-078","source":"Crossref","is-referenced-by-count":5,"title":["Adverse Maternal Outcomes Differ between Obese and Nonobese Women with Severe Preeclampsia"],"prefix":"10.1055","volume":"36","author":[{"given":"Celeste","family":"Durnwald","sequence":"first","affiliation":[{"name":"The Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine \u2013 University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindhu","family":"Srinivas","sequence":"first","affiliation":[{"name":"The Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine \u2013 University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Levine","sequence":"first","affiliation":[{"name":"The Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine \u2013 University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Teefey","sequence":"additional","affiliation":[{"name":"The Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine \u2013 University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,7,6]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1661403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T09:24:53Z","timestamp":1547803493000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1661403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,1,9]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1661403","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]}}}