{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:38:50Z","timestamp":1785386330181,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            Introduction\u2003Pediatric neuroendocrine tumors (NETs) of the appendix are mostly detected incidentally after appendectomy for acute appendicitis. NET management is a matter of controversy. In this national, multicenter study, we aimed to establish guidelines based on our results and the literature.<\/jats:p><jats:p>\n            Materials and Methods\u2003Medical records of children (0\u201316 years) with NET of the appendix, treated in Switzerland (1991\u20132012), were reviewed.<\/jats:p><jats:p>\n            Results\u2003Forty cases (28 girls) were analyzed. Median age at diagnosis was 12.7 years (interquartile range [IQR]: 4.0). Tumor size was 0.1\u201324\u2009mm (median: 0.6, IQR: 0.6). Four patients (10%) underwent additional surgery because of either tumor size\u2009&gt;\u200915\u2009mm (1\/4), extension to the mesoappendix (1\/4), or incomplete resection (2\/4). Three patients with a tumor of\u2009\u2265\u200920\u2009mm had no additional surgery. No patient had lymph node metastases. All patients were in complete remission at the last follow-up (median: 3.0 years, IQR: 10.9).<\/jats:p><jats:p>\n            Conclusion\u2003We conclude from this study and from an extensive review of the literature that two criteria may point to the need for additional surgery, i.e., the possibility of regional lymph node involvement: tumor size\u2009&gt;\u200920\u2009mm and incomplete surgical resection margins. Childhood NET of the appendix has an excellent prognosis.<\/jats:p>","DOI":"10.1055\/s-0038-1667032","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T18:53:29Z","timestamp":1533149609000},"page":"449-457","source":"Crossref","is-referenced-by-count":12,"title":["A National Long-Term Study of Neuroendocrine Tumors of the Appendix in Children: Are We Too Aggressive?"],"prefix":"10.1055","volume":"29","author":[{"given":"Christelle","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hopitaux Universitaires de Geneve Hopital des Enfants, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Gumy Pause","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato-oncology, Hopitaux Universitaires de Geneve Hopital des Enfants, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Diezi","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Hemato-oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Canton of Vaud, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Rougemont","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology, Hopitaux Universitaires de Geneve, Geneva University Hospitals, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hopitaux Universitaires de Geneve Hopital des Enfants, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,8,1]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1667032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T18:31:31Z","timestamp":1571682691000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1667032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2019,10,21]]},"published-print":{"date-parts":[[2019,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1667032","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}