{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:41:21Z","timestamp":1760985681710},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The Mitroflow pericardial bioprosthesis (MPB) has been recently associated with a high incidence of early structural failures, questioning its validity as cardiac valve substitute. We have therefore reviewed our experience with this device.<\/jats:p><jats:p>\n          Materials and Methods\u2003A total of 398 patients with a mean age of 75\u2009\u00b1\u20097 years (58% above the age of 75 years) had aortic valve replacement with a Mitroflow prosthesis (2005\u20132015). Most patients had calcific aortic stenosis (86%) and were in sinus rhythm (89%). Mean EuroSCORE II was 5.5\u2009\u00b1\u20096.2. Mean follow-up was 4\u2009\u00b1\u20092 years (range: 4 months to 10 years), which was 100% complete.<\/jats:p><jats:p>\n          Results\u2003Hospital mortality was 6.5%; at discharge, 25% of patients had a moderate patient\u2013prosthesis mismatch and none had a severe mismatch. Cumulative incidence of structural valve deterioration in the entire series was 2% (95% confidence interval [CI]: 1\u20134) at 5 years and 7% (95% CI: 4\u201314) at 8 years. Significant factors influencing MPB durability were age\u2009\u2264\u200965 years (p\u2009&lt;\u20090.001) and the presence of patient\u2013prosthesis mismatch (p\u2009=\u20090.01). No cases of structural valve deterioration were observed in patients with the new prosthetic model incorporating an anticalcification treatment the first 4 years of follow-up.<\/jats:p><jats:p>\n          Conclusions\u2003The Mitroflow prosthesis has shown satisfactory results in the first decade of use. Durability appears adversely influenced by patient age and patient\u2013prosthesis mismatch. Thus, a careful valve size selection and implantation in patients &gt;65 years of age appears to be associated with excellent valve durability in the aortic position. Whether the new anticalcification treatment will provide a more durable prosthesis must be verified at a longer follow-up.<\/jats:p>","DOI":"10.1055\/s-0038-1667201","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T18:47:30Z","timestamp":1532976450000},"page":"131-140","source":"Crossref","is-referenced-by-count":5,"title":["Durability of the Mitroflow Pericardial Prosthesis: Influence of Patient\u2013Prosthesis Mismatch and New Anticalcification Treatment"],"prefix":"10.1055","volume":"68","author":[{"given":"Stefania","family":"Blasi","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular, University Hospital, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Ravenni","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular, University Hospital, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Celiento","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular, University Hospital, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Martino","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular, University Hospital, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo D.","family":"Milano","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uberto","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Cardiac Thoracic and Vascular, University Hospital, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,7,30]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1667201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T18:36:24Z","timestamp":1583174184000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1667201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,3,2]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1667201","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}