{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:55:38Z","timestamp":1765886138937},"reference-count":32,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"09","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n            Objective\u2003To assess the relationship between the use of psychoactive substances during pregnancy and the occurrence of severe maternal morbidity (SMM), perinatal outcomes and repercussions on the neuropsychomotor development of exposed children.<\/jats:p><jats:p>\n            Methods\u2003A case-control study nested within a cohort of severe maternal morbidity (COMMAG) was performed. Women with SMM were considered cases. Controls were those with low-risk pregnancy, without SMM and admitted during the same time period as the cases. Cohort data were collected retrospectively in hospital records for childbirth. A face-to-face interview was also performed with 638 women (323 without SMM and 315 with SMM) and their children of the index pregnancy between 6 months and 5 years after childbirth. During the interview, substance abuse during pregnancy was assessed by a modified question from the Alcohol, Smoking and Substance Involvement Screening Test 2.0 (ASSIST) and the neuropsychomotor development in the children was assessed by the Denver Developmental Screening Test, 2nd edition.<\/jats:p><jats:p>\n            Results\u2003The prevalence of licit or illicit drug use during pregnancy was \u223c 17%. Among drug users, 63.9% used alcohol, 58.3% used tobacco, 9.2% used cocaine\/crack and 4.6% used marijuana. There was no association between drug use during pregnancy and SMM, although tobacco use during pregnancy was associated with bleeding, presence of near-miss clinical criteria (NMCC) and alteration in infant development; alcohol use was associated with neonatal asphyxia; and cocaine\/crack use was associated with the occurrence of some clinical complications during pregnancy.<\/jats:p><jats:p>\n            Conclusion\u2003The use of psychoactive substances during pregnancy is frequent and associated with worse maternal, perinatal and child development outcomes.<\/jats:p>","DOI":"10.1055\/s-0038-1667291","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T22:55:20Z","timestamp":1533077720000},"page":"518-526","source":"Crossref","is-referenced-by-count":14,"title":["Drug Use during Pregnancy and its Consequences: A Nested Case Control Study on Severe Maternal Morbidity"],"prefix":"10.61622","volume":"40","author":[{"given":"Cynara Maria","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Carvalho","family":"Pacagnella","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Angela","family":"Parpinelli","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Betina","family":"Andreucci","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"},{"name":"Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce Maria","family":"Zanardi","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina Robles","family":"Angelini","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Silveira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Guilherme","family":"Cecatti","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"ref1","volume-title":"World Drug Report 2015","year":"2015"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11920-015-0626-5","article-title":"Substance use in the perinatal period","volume":"17","author":"A Forray","year":"2015","journal-title":"Curr Psychiatry Rep"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/aje\/kwt334","article-title":"Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy","volume":"179","author":"B L Pineles","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/aje\/kwv301","article-title":"Systematic review and meta-analyses of perinatal death and maternal exposure to tobacco smoke during pregnancy","volume":"184","author":"B L Pineles","year":"2016","journal-title":"Am J Epidemiol"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-011-9166-x","article-title":"Fetal alcohol spectrum disorders: an overview","volume":"21","author":"E P Riley","year":"2011","journal-title":"Neuropsychol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ogrm.2010.06.001","article-title":"Alcohol and pregnancy","volume":"20","author":"A Khalil","year":"2010","journal-title":"Obstetrics, Gynaecol Reprod Med"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/acer.12214","article-title":"The association of mild, moderate, and binge prenatal alcohol exposure and child neuropsychological outcomes: a meta-analysis","volume":"38","author":"A L Flak","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"340.e1","DOI":"10.1016\/j.ajog.2010.11.013","article-title":"Knowledge Synthesis group on Determinants of Low Birth Weight and Preterm Births. 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