{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:55Z","timestamp":1787004895241,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Aim\u2003Hepatoblastoma is the most frequent hepatic tumor in children, and its initial presentation will affect treatment and prognosis. The aim of this study is to evaluate long-term results of liver transplantation in children with unresectable hepatoblastoma.<\/jats:p>\n Patients and Methods\u2003This is a retrospective review of patients with hepatoblastoma who underwent liver transplantation, analyzing risk factors, tumor presentation, treatment, and long-term survival to identify prognostic factors.<\/jats:p>\n Results\u2003Thirty-one patients underwent liver transplantation in the context of unresectable hepatoblastoma, mainly males (67%) and with risk factors such as prematurity (12.9%), maternal smoking (6.5%), and familial adenomatous polyposis (3.2%). Most frequent presentation was multifocal PRETEXT III (51.6%) and PRETEXT IV (45.2%), with metastasis at diagnosis in 12.9% and vascular involvement in 54.8%.<\/jats:p>\n Twenty-one patients received a living-donor (67.7%) and 10 a cadaveric graft (32.2%), at 31.7 months of age (5\u2013125). Most transplants were primary, and only two were performed as rescue therapy after an attempt of surgical resection of the tumor.<\/jats:p>\n Overall survival 1 and 5 years after transplantation were 93.3%\u2009\u00b1\u20094.6% and 86.4%\u2009\u00b1\u20096.3%, respectively. We could not find any statistically significant differences between risk factors, tumor presentation, type of graft, or type of transplant.<\/jats:p>\n Conclusion\u2003Liver transplantation has increased hepatoblastoma survival in unresectable tumors. Probably due to these good results, we have not been able to find significant prognostic factors in this cohort.<\/jats:p>","DOI":"10.1055\/s-0038-1668148","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T18:58:20Z","timestamp":1533668300000},"page":"028-032","source":"Crossref","is-referenced-by-count":21,"title":["Prognostic Factors for Liver Transplantation in Unresectable Hepatoblastoma"],"prefix":"10.1055","volume":"29","author":[{"given":"Esther","family":"Cano","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Dore","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Jimenez Gomez","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"S\u00e1nchez Gal\u00e1n","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Vilanova-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Andres","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Encinas","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospiltal Infantil La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Hernandez","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"},{"name":"Department of Pediatric Surgery, Fundacion Investigacion Biomedica Del Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lopez Santamaria","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Triana Junco","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,8,7]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1668148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T18:37:41Z","timestamp":1547750261000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1668148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,1,17]]},"published-print":{"date-parts":[[2019,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1668148","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]}}}