{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:02:42Z","timestamp":1777032162337,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            Introduction\u2003Eosinophilic chronic rhinosinusitis (ECRS) is characterized by an eosinophilic inflammation driven by Th2-type cytokines. Glucocorticosteroids are the most common first-line treatment for ECRS with nasal polyps.<\/jats:p><jats:p>\n            Objective\u2003We have evaluated the long-term treatment with double-dose intranasal corticosteroids in refractory ECRS nasal polyps resistant to the conventional dose and assessed the risk of adverse systemic effects<\/jats:p><jats:p>\n            Methods\u2003Sixteen subjects were enrolled in this study. All subjects had ECRS after endoscopic sinus surgery that resulted in recurrent mild and moderate nasal polyps and were undergoing a postoperative follow-up application of mometasone furoate at a dose of 2 sprays (100 \u03bcg) in each nostril once a day (200 \u03bcg). All the patients were prescribed mometasone furoate, administered at a dose of 2 sprays (100 \u03bcg) in each nostril twice a day (400 \u03bcg) for 6 months.<\/jats:p><jats:p>\n            Results\u2003The average scores of the symptoms during the regular dose of intranasal steroid treatment were 5.2\u2009\u00b1\u20092.2, but 6 months after the high-dose application, they had significantly decreased to 2.5\u2009\u00b1\u20091.4 (p\u2009&lt;\u20090.05). The polyp size showed an average score of 1.38 during the regular dose which was significantly reduced to 0.43 (p\u2009&lt;\u20090.01) by the double dose. Glycated hemoglobin (HbA1c) showed normal ranges in all the patients tested. The cortisol plasma concentration was also normal.<\/jats:p><jats:p>\n            Conclusion\u2003Doubling the dose of the nasal topical spray mometasone furoate might be recommended for the treatment of recurrent nasal polyps in the postoperative follow-up of intractable ECRS.<\/jats:p>","DOI":"10.1055\/s-0038-1668515","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T18:49:27Z","timestamp":1540406967000},"page":"101-103","source":"Crossref","is-referenced-by-count":13,"title":["Postoperative Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: Impact of High-Dose Corticosteroid Nasal Spray"],"prefix":"10.1055","volume":"23","author":[{"given":"Katsuhisa","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi","family":"Hibiya","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotomo","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritsugu","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Kidokoro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Juntendo University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,10,24]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1668515.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:16:43Z","timestamp":1557163003000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1668515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,24]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,1,14]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1668515","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,24]]}}}