{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:02:28Z","timestamp":1779210148741,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n            Background\u2003Management of pregnant women at risk of venous thromboembolism (VTE) and placental vascular complications (PVCs) remains complex. Guidelines do not definitively specify optimal strategies.<\/jats:p><jats:p>\n            Objective\u2003Our objective was to evaluate the impact of employing risk score-driven prophylaxis strategies on VTE and PVC rates in at-risk pregnant women.<\/jats:p><jats:p>\n            Materials and Methods\u2003This study, conducted in 21 French maternity units, compared VTE and PVC rates before and after implementation of a risk scoring system to determine prophylactic strategies.<\/jats:p><jats:p>\n            Results\u2003A total of 2,085 pregnant women at risk of VTE or PVC were enrolled. Vascular events occurred in 190 (19.2%) patients before and 140 (13.0%) after implementation of risk score-driven prophylaxis (relative risk [RR]\u2009=\u20090.68 [0.55; 0.83]). The incidence of deep vein thrombosis during pregnancy was reduced (RR\u2009=\u20090.30 [0.14; 0.67]). PVC comprised mainly pre-eclampsia, occurring in 79 patients before and 42 patients after risk score implementation (RR\u2009=\u20090.52 [0.36; 0.75]). Post-partum haemorrhage occurred in 32 patients (3.2%) before and 48 patients (4.5%) after risk score implementation (RR\u2009=\u20091.38 [0.89; 2.13], p\u2009=\u20090.15).<\/jats:p><jats:p>\n            Conclusion\u2003Use of a simple risk scoring system, developed by experts in VTE and PVC research to guide prophylaxis, reduced the risk of thrombotic events during pregnancy without any significant increase in bleeding risk.<\/jats:p>","DOI":"10.1055\/s-0038-1668524","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T18:59:26Z","timestamp":1534186766000},"page":"1564-1571","source":"Crossref","is-referenced-by-count":26,"title":["Benefit of Risk Score-Guided Prophylaxis in Pregnant Women at Risk of Thrombotic Events: A Controlled Before-and-After Implementation Study"],"prefix":"10.1055","volume":"118","author":[{"given":"C\u00e9line","family":"Chauleur","sequence":"additional","affiliation":[{"name":"INSERM U1059, Saint-Etienne, France"},{"name":"University of Lyon, Saint-Etienne, France"},{"name":"Department of Gynecology and Obstetrics, University Hospital of Saint-Etienne, Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Gris","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of N\u00eemes, N\u00eemes, France"},{"name":"UPRES EA2990, University of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvy","family":"Laporte","sequence":"additional","affiliation":[{"name":"INSERM U1059, Saint-Etienne, France"},{"name":"University of Lyon, Saint-Etienne, France"},{"name":"Clinical Pharmacology Department, University Hospital of Saint-Etienne, Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Chapelle","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, University Hospital of Saint-Etienne, Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[{"name":"INSERM U1059, Saint-Etienne, France"},{"name":"Clinical Pharmacology Department, University Hospital of Saint-Etienne, Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Equy","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Grenoble University Hospital, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Gaucherand","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospices Civils de Lyon, H\u00f4pital Femme M\u00e8re Enfant, Bron Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Bazan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Mont\u00e9limar Hospital, Mont\u00e9limar, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospices Civils de Lyon, H\u00f4pital Lyon-Sud, Pierre-B\u00e9nite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Gallot","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Mismetti","sequence":"additional","affiliation":[{"name":"INSERM U1059, Saint-Etienne, France"},{"name":"University of Lyon, Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The STRATHEGE Investigators and The STRATHEGE Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,8,13]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1668524.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T16:56:18Z","timestamp":1557161778000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1668524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2018,9,14]]},"published-print":{"date-parts":[[2018,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1668524","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]}}}