{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:05:43Z","timestamp":1761102343100},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":103,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aorta"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n            Background\u2003Floppy mitral valve\/mitral valve prolapse (FMV\/MVP), a heritable disorder of connective tissue, often leads to mitral regurgitation (MR) and is the most common cause for mitral valve surgery in developed countries. Connective tissue disorders may affect aortic function, and a stiff aorta may increase the severity of MR. Aortic function, however, has not been studied in FMV\/MVP with MR.<\/jats:p><jats:p>\n            Methods\u2003A total of 17 patients (11 men, 6 women) with FMV\/MVP and significant MR were compared with 20 controls matched for age and gender. Aortic diameters (AoD) were measured from left ventriculograms at 2 and 4 cm above the aortic valve. Aortic pressures were measured directly using fluid-filled catheters. Aortic distensibility was calculated using the formula: 2(systolic AoD\u2014diastolic AoD)\/(diastolic AoD x pulse pressure).<\/jats:p><jats:p>\n            Results\u2003Aortic distensibility was significantly lower in FMV\/MVP compared with control at 2 cm above the aortic valve (1.00\u2009\u00b1\u20090.19 versus 3.78\u2009\u00b1\u20091.10 10\u22123 mm Hg\u22121, respectively; p\u2009=\u20090.027) and 4 cm above the aortic valve (0.89\u2009\u00b1\u20090.16 versus 3.22\u2009\u00b1\u20090.19 10\u22123 mm Hg\u22121, respectively; p\u2009=\u20090.007). FMV\/MVP patients had greater left ventricular (LV) end-systolic (88\u2009\u00b1\u200972 mL versus 35\u2009\u00b1\u200915 mL, p\u2009=\u20090.002) and end-diastolic (165\u2009\u00b1\u200989 mL versus 100\u2009\u00b1\u200941 mL, p\u2009=\u20090.005) volumes, and lower LV ejection fraction, compared with control (50\u2009\u00b1\u200912% versus 57\u2009\u00b1\u20096%, p\u2009=\u20090.034).<\/jats:p><jats:p>\n            Conclusion\u2003Aortic distensibility is decreased (consistent with a stiff aorta) in patients with FMV\/MVP and MR. A stiff aorta may increase the severity of MR. Thus, abnormal aortic function, which also deteriorates with age, may play an important role in the natural history of MR due to FMV\/MVP.<\/jats:p>","DOI":"10.1055\/s-0038-1669417","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T18:37:36Z","timestamp":1536777456000},"page":"075-080","source":"Crossref","is-referenced-by-count":3,"title":["Aortic Dysfunction in Mitral Regurgitation Due to Floppy Mitral Valve\/Mitral Valve Prolapse"],"prefix":"10.1055","volume":"06","author":[{"given":"Hatem","family":"Mowafy","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, Ohio"},{"name":"Critical Care Department, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Lilly","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Orsinelli","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Rushing","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Crestanello","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Boudoulas","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,9,12]]},"container-title":["AORTA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1669417.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:21:38Z","timestamp":1557163298000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1669417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,2,22]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1669417","relation":{},"ISSN":["2325-4637"],"issn-type":[{"value":"2325-4637","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}