{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:34:13Z","timestamp":1791941653110,"version":"4.3.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n            Objective\u2003Obesity during pregnancy impedes fetal iron endowment. In adults, both iron depletion and hypoxia stimulate erythropoietin (Epo) production, while hepcidin, the primary iron regulator, is inhibited by Epo and stimulated by obesity. To understand this relationship in fetuses, we investigated obesity, inflammation, and fetal iron status on fetal Epo and hepcidin levels.<\/jats:p><jats:p>\n            Study Design\u2003Epo, hepcidin, C-reactive protein (CRP), and ferritin levels were measured in 201 newborns of 35 to 40 weeks' gestation with historical risk factors for a low fetal iron endowment, including half with maternal obesity.<\/jats:p><jats:p>\n            Results\u2003Epo was unrelated to fetal size, but Epo was directly related to maternal body mass index (BMI; kg\/m2) (p\u2009&lt;\u20090.03) and CRP (p\u2009&lt;\u20090.0005) at delivery. Epo levels were twice as likely to be elevated (\u226550 IU\/L) while comparing the lowest quartile of ferritin with the upper three quartiles (p\u2009&lt;\u20090.01). Hepcidin was directly related to ferritin (p\u2009&lt;\u20090.001) and indirectly related to maternal BMI (p\u2009&lt;\u20090.015), but BMI became nonsignificant when undergoing multivariate analysis. Hepcidin was unrelated to Epo.<\/jats:p><jats:p>\n            Conclusion\u2003Although some of the fetal responses involving Epo were similar to adults, we did not find a hepcidin\u2013Epo relationship like that of adults, where fetal liver is the site of both hepcidin and Epo production.<\/jats:p>","DOI":"10.1055\/s-0038-1669444","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T22:47:16Z","timestamp":1536360436000},"page":"511-516","source":"Crossref","is-referenced-by-count":11,"title":["Cord Blood Erythropoietin and Hepcidin Reflect Lower Newborn Iron Stores due to Maternal Obesity during Pregnancy"],"prefix":"10.1055","volume":"36","author":[{"given":"Colin","family":"Korlesky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin"},{"name":"Department of Pediatrics, UnityPoint Health-Meriter, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Kling","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin"},{"name":"Department of Pediatrics, UnityPoint Health-Meriter, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Wisconsin-Parkside, Kenosha, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Ovasapyan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Wisconsin-Parkside, Kenosha, Wisconsin"},{"name":"North Central Health Care, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Leyns","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Wisconsin-Parkside, Kenosha, Wisconsin"},{"name":"Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UnityPoint Health-Meriter, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin"},{"name":"Department of Orthopedics, Case Western Reserve, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Coe","sequence":"additional","affiliation":[{"name":"Department of Psychology, Harlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,9,7]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1669444.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T22:44:40Z","timestamp":1554245080000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1669444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2019,4,2]]},"published-print":{"date-parts":[[2019,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1669444","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]}}}