{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:13:41Z","timestamp":1778829221249,"version":"3.51.4"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"09","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n            Objective\u2003To determine the frequency of sexually transmitted infections (STIs) in asymptomatic women and the association of STIs with cervical intraepithelial neoplasia (CIN).<\/jats:p><jats:p>\n            Methods\u2003A cross-sectional study was performed, enrolling women examined in a general gynecology clinic and in a colposcopy referral center from October 2014 to October 2015. The colposcopy group consisted of 71 women, and the general gynecology group consisted of 55 women. Cervical samples were collected for cervical cytology and a multiplex real-time polymerase chain reaction (PCR) was developed to detect human papillomavirus (HPV) and the STIs caused by the following microorganisms: Chlamydia trachomatis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, and Neisseria gonorrhoeae. A multivariate analysis was performed by logistic regression, considering the significance level of 0.05.<\/jats:p><jats:p>\n            Results\u2003The general frequency of STIs was: 46.8% (HPV); 27.8% (C. trachomatis); 28.6% (M. genitalium); 0.8% (M. hominis); 4.8% (U. urealyticum); and 4.8% (N. gonorrhoeae). The significant risk factors for CIN were: HPV infection (odds ratio [OR]\u2009=\u20092.53; p\u2009=\u20090.024); C. trachomatis (OR\u2009=\u20093.04; p\u2009=\u20090.009); M. genitalium (OR\u2009=\u20092.37; p\u2009=\u20090.04); and HPV and C. trachomatis coinfection (OR\u2009=\u20093.11; p\u2009=\u20090.023). After the multivariate analysis, a significant association was found between HPV and CIN (OR\u2009=\u20092.48; 95% confidence interval [95%CI]: 1.04\u20135.92; p\u2009=\u20090.04); and between C. trachomatis and CIN (OR\u2009=\u20092.69; 95%CI: 1.11\u20136.53; p\u2009=\u20090.028).<\/jats:p><jats:p>\n            Conclusion\u2003The frequency of STIs was high in asymptomatic patients. Infections by HPV and C. trachomatis were independently associated with the presence of CIN. The high frequency of STIs in asymptomatic women suggests the need for routine screening of these infections.<\/jats:p>","DOI":"10.1055\/s-0038-1669994","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T22:44:36Z","timestamp":1537397076000},"page":"540-546","source":"Crossref","is-referenced-by-count":18,"title":["Sexually Transmitted Infections Detected by Multiplex Real Time PCR in Asymptomatic Women and Association with Cervical Intraepithelial Neoplasia"],"prefix":"10.61622","volume":"40","author":[{"given":"Luiza de Miranda","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Ren\u00e9","family":"Hoelzle","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Toscano","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria In\u00eas de Miranda","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o e Pesquisa da Santa Casa, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordana Rodrigues Barbosa","family":"Fradico","sequence":"additional","affiliation":[{"name":"Research and Development Division, Grupo Hermes Pardini, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvis Cristian Cueva","family":"Mateo","sequence":"additional","affiliation":[{"name":"Research and Development Division, Grupo Hermes Pardini, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Alves Gomes","family":"Zauli","sequence":"additional","affiliation":[{"name":"Research and Development Division, Grupo Hermes Pardini, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Hugo","family":"Melo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1590\/S1413-86702011000600011","article-title":"Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina","volume":"15","author":"G D Deluca","year":"2011","journal-title":"Braz J Infect 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