{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:31:11Z","timestamp":1793907071656,"version":"4.8.0"},"reference-count":0,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Genet"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unexplained childhood fracture(s) warrant consideration of physical abuse and osteogenesis imperfecta (OI). Genetic OI testing may identify \u201cvariants of unknown significance (VUS).\u201d Interpretation of VUS in context of potential abuse may have protective, criminal, and medical impacts. This case series explores practices regarding clinicians' interpretation of VUS during child abuse evaluations. Variability was noted regarding factors considered for interpreting clinical significance. Based on these cases, recommendations for careful and thorough evaluation are detailed, including proposed use of a limited follow-up skeletal survey in 3 months, as a consideration to assess healing of prior fractures and to look for any additional injuries.<\/jats:p>","DOI":"10.1055\/s-0038-1672135","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T18:49:30Z","timestamp":1537555770000},"page":"063-068","source":"Crossref","is-referenced-by-count":6,"title":["Interpreting Osteogenesis Imperfecta Variants of Uncertain Significance in the Context of Physical Abuse: A Case Series"],"prefix":"10.53391","volume":"08","author":[{"given":"Jennifer","family":"Canter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College, Valhalla, New York, United States"},{"name":"Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College, Valhalla, New York, United States"},{"name":"Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Palusci","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kronn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College, Valhalla, New York, United States"},{"name":"Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Manaster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College, Valhalla, New York, United States"},{"name":"Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Altman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Medical College, Valhalla, New York, United States"},{"name":"Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31409","published-online":{"date-parts":[[2018,9,21]]},"container-title":["Journal of Pediatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1672135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:45:38Z","timestamp":1758138338000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1672135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,21]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,5,3]]},"published-print":{"date-parts":[[2019,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1672135","relation":{},"ISSN":["2146-4596","2146-460X"],"issn-type":[{"value":"2146-4596","type":"print"},{"value":"2146-460X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,21]]}}}