{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:55Z","timestamp":1787004895746,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Objectives\u2003The objective of this registry was to study the safety of prehospital initiation of ticagrelor compared with clopidogrel.<\/jats:p>\n                  <jats:p>Background\u2003Ticagrelor has replaced clopidogrel in many hospitals as the routinely used antiplatelet drug in patients with ST-segment elevation myocardial infarction (STEMI). Nevertheless, in the PLATelet inhibition and patient Outcomes (PLATO) trial, ticagrelor was associated with an increase in non-CABG (non\u2013coronary artery bypass grafting)-related major bleeding. Data comparing the safety of ticagrelor and clopidogrel after prehospital initiation of treatment are not available.<\/jats:p>\n                  <jats:p>Methods\u2003A retrospective, multicenter registry was performed. Selection criteria were the administration of a prehospital loading dose of ticagrelor or clopidogrel according to the ambulance STEMI treatment protocol and the presentation to a percutaneous coronary intervention\u2013capable hospital in our region between January 2011 and December 2012. Follow-up was performed using the electronic patient files for the time period between the antiplatelet loading dose and hospital discharge. The data were analyzed using a primary bleeding end point (any bleeding) and a secondary thrombotic end point (all-cause mortality, spontaneous myocardial infarction, definite stent thrombosis, stroke, or transient ischemic attack).<\/jats:p>\n                  <jats:p>Results\u2003Data of 304 clopidogrel-treated and 309 ticagrelor-treated patients were available for analysis. No significant difference in bleeding rate was observed between both groups, using univariate (17.8 vs. 20.1%; p\u2009=\u20090.47; odds ratio, 1.16 [95% confidence interval, 0.78\u20131.74]) and multivariate (p\u2009=\u20090.42) analysis. Also for the secondary thrombotic end point (6.3 vs. 4.9%, p\u2009=\u20090.45), no significant differences were observed.<\/jats:p>\n                  <jats:p>Conclusion\u2003In this real-world registry, no significant differences in bleeding or thrombotic event rate were found between ticagrelor and clopidogrel after prehospital initiation of treatment.<\/jats:p>","DOI":"10.1055\/s-0038-1673389","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T19:02:58Z","timestamp":1539284578000},"page":"e357-e368","source":"Crossref","is-referenced-by-count":3,"title":["Safety of Ticagrelor Compared to Clopidogrel after Prehospital Initiation of Treatment"],"prefix":"10.1055","volume":"02","author":[{"given":"Thomas","family":"Bergmeijer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs","family":"van Oevelen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Godschalk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lichtveld","sequence":"additional","affiliation":[{"name":"Regional Ambulance Service Utrecht (RAVU), Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kelder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Voskuil","sequence":"additional","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology, UMC Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend","family":"Mosterd","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Meander Medical Center, Amersfoort, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"ACTION Study Group, UPMC Sorbonne Universit\u00e9s, Piti\u00e9-Salp\u00eatri\u00e8re Hospital (AP-HP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurri\u00ebn","family":"ten Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,10,11]]},"container-title":["TH Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1673389.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:05:02Z","timestamp":1557162302000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1673389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,10,1]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1673389","relation":{},"ISSN":["2512-9465"],"issn-type":[{"value":"2512-9465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}