{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:52:30Z","timestamp":1782899550594,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of acquired von Willebrand syndrome (AvWS) in patients with heart disease is commonly perceived as rare. However, its occurrence is underestimated and underdiagnosed, potentially leading to inadequate treatment resulting in increased morbidity and mortality.<\/jats:p><jats:p>In patients with cardiac disease, AvWS frequently occurs in patients with structural heart disease and in those undergoing mechanical circulatory support (MCS).<\/jats:p><jats:p>The clinical manifestation of an AvWS is usually characterized by apparent or occult gastrointestinal (GI) or mucocutaneous hemorrhage frequently accompanied by signs of anemia and\/or increased bleeding during surgical procedures. The primary change is loss of high-molecular weight von Willebrand factor multimers (HMWM). Whereas the loss of HMWM in patients with structural heart disease is caused by increased HMWM cleavage by von Willebrand factor (vWF)-cleaving protease, ADAMTS13, AvWS in MCS patients is predominantly a result of a high shear stress coupled with mechanical destruction of vWF itself.<\/jats:p><jats:p>This manuscript provides a comprehensive review of the evidence regarding both diagnosis and contemporary management of AVWS in patients with heart disease.<\/jats:p>","DOI":"10.1055\/s-0038-1673670","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:31Z","timestamp":1542758431000},"page":"200-211","source":"Crossref","is-referenced-by-count":6,"title":["Diagnosis and Management of Acquired von Willebrand Disease in Heart Disease: A Review of the Literature"],"prefix":"10.1055","volume":"68","author":[{"given":"Mate","family":"Petricevic","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadranka","family":"Knezevic","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, University Hospital Center Mostar, Mostar, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordan","family":"Samoukovic","sequence":"additional","affiliation":[{"name":"Divisions of Cardiac Surgery and Critical Care, Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Bradaric","sequence":"additional","affiliation":[{"name":"Merkur University Hospital, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Disease, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Safradin","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Mestrovic","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasil","family":"Papestiev","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alen","family":"Hodalin","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomislav","family":"Madzar","sequence":"additional","affiliation":[{"name":"University of Osijek School of Medicine, Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mihalj","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Split School of Medicine, University Hospital Center Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante","family":"Rotim","sequence":"additional","affiliation":[{"name":"University of Osijek School of Medicine, Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Biocina","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,11,20]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1673670.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T22:37:58Z","timestamp":1586385478000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1673670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,4,8]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1673670","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]}}}