{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:55:35Z","timestamp":1790963735280,"version":"4.1.0"},"reference-count":35,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"11","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n            Objective\u2003Does the use of metformin have an influence on the outcomes of preeclampsia (PE)?<\/jats:p><jats:p>\n            Sources of Data\u2003The descriptors pregnancy, metformin, treatment, and preeclampsia associated with the Boolean operators AND and OR were found in the MEDLINE, LILACS, Embase and Cochrane databases. A flowchart with exclusion criteria and inclusion strategy using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, and eligibility criteria was used. Data were extracted regarding the type of study, the applied dosage, treatment time, segment, bias risks, and the Patient, Intervention, Comparison and Outcome (PICO) strategy to identify the quality of the study.<\/jats:p><jats:p>\n            Selection of Studies\u2003Total number of journals in the initial search (n\u2009=\u2009824); exclusions from repeated articles on different search engines (n\u2009=\u2009253); exclusions after reading the titles, when the title had no correlations with the proposed theme (n\u2009=\u2009164); exclusions due to incompatibility with the criteria established in the methodological analysis (n\u2009=\u2009185), exclusion of articles with lower correlation with the objective of the present study (n\u2009=\u2009187); and final bibliographic selection (n\u2009=\u200935).<\/jats:p><jats:p>\n            Data Collection\u2003At first, a systematic review of the literature was performed. Subsequently, from the main selection, randomized and non-randomized trials with metformin that presented their results in absolute and relative numbers of PE outcomes were selected. The variables were treated statistically in the meta-analysis with the Review Manager software (RevMan), version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration. Denmark in the Hovedistaden region.<\/jats:p><jats:p>\n            Synthesis of Data\u2003The study showed that metmorfin presented greater preventive effects for pregnancy-induced hypertension and was less effective for PE.<\/jats:p><jats:p>\n            Conclusion\u2003Metformin may gain place in preventive treatments for PE, once the dosages, the gestational age, and treatment time are particularly evaluated. A methodological strategy with an improved perspective of innovative and\/or carefully progressive dosages during pregnancy to avoid side effects and the possibility of maternal-fetal risks is suggested.<\/jats:p>","DOI":"10.1055\/s-0038-1675214","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:20:25Z","timestamp":1541550025000},"page":"713-721","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of Preeclampsia Results after Use of Metformin in Gestation: Systematic Review and Meta-analysis"],"prefix":"10.61622","volume":"40","author":[{"given":"Iramar Baptistella do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Postgraduate in Health and Environment, Universidade da Regi\u00e3o de Joinville, Joinville, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Dienstmann","sequence":"additional","affiliation":[{"name":"Department of Postgraduate in Health and Environment, Universidade da Regi\u00e3o de Joinville, Joinville, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Leite Ramos","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Postgraduate in Health and Environment, Universidade da Regi\u00e3o de Joinville, Joinville, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Fleig","sequence":"additional","affiliation":[{"name":"Department of Postgraduate in Health and Environment, Universidade da Regi\u00e3o de Joinville, Joinville, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Beatriz Pimentel Cesar","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Postgraduate in Health and Environment, Universidade da Regi\u00e3o de Joinville, Joinville, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean 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