{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T05:57:40Z","timestamp":1721800660421},"reference-count":58,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"11","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n            Objective\u2003To characterize the patterns of cell differentiation, proliferation, and tissue invasion in eutopic and ectopic endometrium of rabbits with induced endometriotic lesions via a well- known experimental model, 4 and 8 weeks after the endometrial implantation procedure.<\/jats:p><jats:p>\n            Methods\u2003Twenty-nine female New Zealand rabbits underwent laparotomy for endometriosis induction through the resection of one uterine horn, isolation of the endometrium, and fixation of tissue segment to the pelvic peritoneum. Two groups of animals (one with 14 animals, and the other with15) were sacrificed 4 and 8 weeks after endometriosis induction. The lesion was excised along with the opposite uterine horn for endometrial gland and stroma determination. Immunohistochemical reactions were performed in eutopic and ectopic endometrial tissues for analysis of the following markers: metalloprotease (MMP-9) and tissue inhibitor of metalloprotease (TIMP-2), which are involved in the invasive capacity of the endometrial tissue; and metallothionein (MT) and p63, which are involved in cell differentiation and proliferation.<\/jats:p><jats:p>\n            Results\u2003The intensity of the immunostaining for MMP9, TIMP-2, MT, and p63 was higher in ectopic endometria than in eutopic endometria. However, when the ectopic lesions were compared at 4 and 8 weeks, no significant difference was observed, with the exception of the marker p63, which was more evident after 8 weeks of evolution of the ectopic endometrial tissue.<\/jats:p><jats:p>\n            Conclusion\u2003Ectopic endometrial lesions seem to express greater power for cell differentiation and tissue invasion, compared with eutopic endometria, demonstrating a potentially invasive, progressive, and heterogeneous presentation of endometriosis.<\/jats:p>","DOI":"10.1055\/s-0038-1675612","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:27:09Z","timestamp":1543451229000},"page":"705-712","source":"Crossref","is-referenced-by-count":4,"title":["Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study"],"prefix":"10.61622","volume":"40","author":[{"given":"Ver\u00f4nica Cristina Moraes","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"},{"name":"Faculty of Medicine, Universidade Federal do Mato Grosso, Cuiaba, MT, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Meola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Britto","family":"Garcia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jos\u00e9","family":"Candido-dos-Reis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omero Benedicto","family":"Poli-Neto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Alberto","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Cesar","family":"Rosa-e-Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and 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