{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:24:36Z","timestamp":1788362676269,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n            Objective\u2003To evaluate the initial doses of surfactant administered to preterm infants with respiratory distress syndrome.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study of 206 preterm infants admitted in four level III neonatal intensive care units of acute tertiary care hospitals in Spain between 2013 and 2015.<\/jats:p><jats:p>\n            Results\u2003The mean initial dose of surfactant was 173.9 (37.3) mg\/kg, and 47.5% of infants received a dose of 200 mg\/kg\u2009\u00b1\u200910% (180\u2013220 mg\/kg), 47% less than 180 mg\/kg (\u201310%), and 5.4% more than 220 mg\/kg (+10%). Very preterm infants (&lt;28 weeks) received higher initial doses than more mature infants, but in all cases, the mean doses were below the recommended 200 mg\/kg (by 9.2% in gestational age 23\u201328 weeks, by 15.9% in 29\u201332 weeks, and by 24.3% in &gt;32 weeks).<\/jats:p><jats:p>\n            Conclusion\u2003Administration of surfactant below the prescribed dose is a frequent error in clinical practice. Inadvertently rounding down doses seems a plausible explanation.<\/jats:p>","DOI":"10.1055\/s-0038-1675645","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T23:43:51Z","timestamp":1541893431000},"page":"943-948","source":"Crossref","is-referenced-by-count":11,"title":["Underdosing of Surfactant for Preterm Babies with Respiratory Distress Syndrome in Clinical Practice: A Retrospective Cohort Study"],"prefix":"10.1055","volume":"36","author":[{"given":"Hector","family":"Boix","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segundo","family":"Rite","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Hospital Universitario Miguel Servet, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Arruza","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Serrano","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Hospital Universitario Miguel Servet, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Baquedano","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Hospital Universitario Miguel Servet, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dolores","family":"Elorza","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,11,10]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1675645.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T10:22:47Z","timestamp":1564395767000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1675645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,10]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2019,7,15]]},"published-print":{"date-parts":[[2019,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1675645","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,10]]}}}