{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:06:27Z","timestamp":1774793187354,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n            Objective\u2003To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC).<\/jats:p><jats:p>\n            Study Design\u2003Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC and OB-NEC groups. OB was administered to the OB-control and OB-NEC groups. Macroscopic scoring of the intestinal tract was evaluated and tissue samples were obtained for histopathological and biochemical examination on the fourth day.<\/jats:p><jats:p>\n            Results\u2003OB improved the macroscopic appearance of the gut and the clinical score during the experiment (p\u2009\u2009&lt;\u2009\u20090.05). The rate of occurrence of NEC in the OB-NEC group was lower than the NEC group (p\u2009\u2009=\u2009\u20090.001). OB prevented necrosis and reduced the number of apoptotic cells in the OB-NEC group compared with the NEC group (p\u2009\u2009=\u2009\u20090.006). Furthermore, interleukin-6 and malondialdehyde levels in the OB-NEC group were lower than the NEC group (p\u2009\u2009&lt;\u2009\u20090.05).<\/jats:p><jats:p>\n            Conclusion\u2003OB reduced intestinal damage and prevented necrosis through anti-inflammatory and antiapoptotic effects in experimental NEC. This effect of OB should be confirmed in clinical studies. Furthermore, future research should investigate whether OB plays a role in NEC pathogenesis or NEC is associated with OB levels in the serum and in breast milk.<\/jats:p>","DOI":"10.1055\/s-0038-1676491","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T18:46:17Z","timestamp":1545245177000},"page":"1179-1187","source":"Crossref","is-referenced-by-count":3,"title":["Obestatin Reduces Intestinal Damage in Experimental Necrotizing Enterocolitis in Newborn Rats"],"prefix":"10.1055","volume":"36","author":[{"given":"Sabriye","family":"Korkut","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu Han\u0131m","family":"Yay","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahir","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cevat","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130nayet","family":"G\u00fcnt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Kurto\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,12,19]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1676491.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T18:39:36Z","timestamp":1567795176000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1676491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,9,6]]},"published-print":{"date-parts":[[2019,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1676491","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}