{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:23:51Z","timestamp":1787318631504,"version":"build-2736575974"},"reference-count":36,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"01","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Objective\u2003To evaluate the prevalence of metabolic syndrome (MetS) in the phenotypes of polycystic ovarian syndrome (PCOS).<\/jats:p>\n                  <jats:p>Methods\u2003This was a cross-sectional study involving 111 women aged between 18 and 39 years old diagnosed with PCOS, according to the Rotterdam Criteria, and grouped into four phenotypes: A: ovulatory dysfunction\u2009+\u2009hyperandrogenism\u2009+\u2009polycystic ovaries; B: ovulatory dysfunction\u2009+\u2009hyperandrogenism; C: hyperandrogenism\u2009+\u2009polycystic ovaries; D: ovulatory dysfunction\u2009+\u2009polycystic ovaries. To evaluate the presence of MetS, we measured serum triglyceride levels, HDL cholesterol, fasting blood glucose, blood pressure, and waist circumference.<\/jats:p>\n                  <jats:p>Results\u2003The prevalence of MetS found in this sample was 33.6%, and there was no statistically significant difference (p\u2009&lt;\u20090.05) among the 4 phenotypes. However, phenotype D presented a significantly higher mean glucose level after fasting (93.6 mg\/dL) and 2 hours after ingesting a solution with 75\u2009g of anhydrous glucose (120 mg\/dL), as well as the lowest mean level of high-density lipoprotein (HDL) cholesterol (44.7 mg\/dL). The women in this group demonstrated a high prevalence of abdominal circumference\u2009\u2265\u200980 cm (68.2%), as well as the highest mean abdominal circumference (90.1 cm). Amongst the women with an abdominal circumference\u2009\u2265\u200980 cm, phenotype A increased approximately six-fold the chance of developing metabolic syndrome in relation to phenotype C.<\/jats:p>\n                  <jats:p>Conclusion\u2003The four phenotypes of PCOS demonstrated similar prevalence rates of metabolic syndrome; abdominal obesity presented a relevant role in the development of metabolic alterations, regardless of the phenotype.<\/jats:p>","DOI":"10.1055\/s-0038-1676568","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T18:31:17Z","timestamp":1549305077000},"page":"037-043","source":"Crossref","is-referenced-by-count":28,"title":["The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome"],"prefix":"10.61622","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-7031","authenticated-orcid":false,"given":"Aleide","family":"Tavares","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romualda Castro","family":"R\u00eago Barros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"B C Fauser","year":"2012","journal-title":"Fertil Steril"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"J Chang","year":"2004","journal-title":"Fertil Steril"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.fertnstert.2014.08.001","article-title":"Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?","volume":"102","author":"N M Daan","year":"2014","journal-title":"Fertil Steril"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/humrep\/des232","article-title":"Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria","volume":"27","author":"B O Yildiz","year":"2012","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CLEP.S37559","article-title":"Epidemiology, diagnosis, and management of polycystic ovary syndrome","volume":"6","author":"S M Sirmans","year":"2013","journal-title":"Clin Epidemiol"},{"issue":"03","key":"ref6","first-page":"127","article-title":"LAP (produto da acumula\u00e7\u00e3o lip\u00eddica) e s\u00edndrome metab\u00f3lica em pacientes com s\u00edndrome dos ov\u00e1rios polic\u00edsticos","volume":"30","author":"J A Dias","year":"2015","journal-title":"Reprod Clim."},{"key":"ref7","first-page":"118","article-title":"Marcadores moleculares e bioqu\u00edmicos para a s\u00edndrome dos ov\u00e1rios polic\u00edsticos","volume":"9","author":"M D Antunes","year":"2014","journal-title":"SaBios"},{"key":"ref8","first-page":"199","article-title":"A import\u00e2ncia da idade na s\u00edndrome metab\u00f3lica em pacientes portadoras de ov\u00e1rios polic\u00edsticos","volume":"9","author":"L Habib","year":"2016","journal-title":"Int J Neurol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.fertnstert.2010.02.015","article-title":"Variation in metabolic and cardiovascular risk in women with different polycystic ovary syndrome phenotypes","volume":"94","author":"D Wiltgen","year":"2010","journal-title":"Fertil Steril"},{"key":"ref10","first-page":"32","article-title":"S\u00edndrome dos ov\u00e1rios polic\u00edsticos em um servi\u00e7o de refer\u00eancia: preval\u00eancia e risco cardiovascular associado","volume":"13","author":"G IM Freire","year":"2012","journal-title":"Rev Pesq Sa\u00fade."},{"issue":"03","key":"ref11","first-page":"111","article-title":"[Cardiovascular risk markers in polycystic ovary syndrome in women with and without insulin resistance]","volume":"31","author":"WdeP Martins","year":"2009","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"01","key":"ref12","first-page":"4","article-title":"[Women with polycystric ovary syndrome have a higher frequency of metabolic syndrome regardless of body mass index]","volume":"34","author":"A S Melo","year":"2012","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1590\/0004-2730000003051","article-title":"Polycystic ovary syndrome: reviewing diagnosis and management of metabolic disturbances","volume":"58","author":"P M Spritzer","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/jc.2009-2724","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society","volume":"95","author":"R A Wild","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.fertnstert.2010.12.027","article-title":"Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis","volume":"95","author":"R A Wild","year":"2011","journal-title":"Fertil Steril"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"E628","DOI":"10.1210\/jc.2012-3908","article-title":"Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome","volume":"98","author":"P Moghetti","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"01","key":"ref17","first-page":"33","article-title":"Obesidade e s\u00edndrome dos ov\u00e1rios polic\u00edsticos: v\u00ednculo fisiopatol\u00f3gico e impacto no fen\u00f3tipo das pacientes","volume":"13","author":"L M Le\u00e3o","year":"2014","journal-title":"Rev HUPE"},{"issue":"06","key":"ref18","first-page":"310","article-title":"[Metabolic abnormalities in polycystic ovary syndrome women: obese and non obese]","volume":"33","author":"L G Romano","year":"2011","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.fertnstert.2009.04.021","article-title":"Not all women diagnosed with PCOS share the same cardiovascular risk profiles","volume":"94","author":"V P Jovanovic","year":"2010","journal-title":"Fertil Steril"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.fertnstert.2014.02.020","article-title":"Metabolic profile of the different phenotypes of polycystic ovary syndrome in two Latin American populations","volume":"101","author":"A Ladr\u00f3n de Guevara","year":"2014","journal-title":"Fertil Steril"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/jc.2004-2279","article-title":"Phenotypic variation in hyperandrogenic women cardiovascular risk parameters","volume":"90","author":"E Carmina","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.fertnstert.2014.01.049","article-title":"Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome","volume":"101","author":"J J Kim","year":"2014","journal-title":"Fertil Steril"},{"issue":"09","key":"ref23","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1590\/S0004-27302007000900014","article-title":"S\u00edndrome metab\u00f3lica, seus fen\u00f3tipos e resist\u00eancia \u00e0 insulina pelo HOMA-RI","volume":"51","author":"E P Oliveira","year":"2007","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1758-5996-4-38","article-title":"Prevalence of the metabolic syndrome using two proposed definitions in a Japanese-Brazilians community","volume":"4","author":"M C Foss-Freitas","year":"2012","journal-title":"Diabetol Metab Syndr"},{"key":"ref25","first-page":"1","article-title":"7a Diretriz Brasileira de Hipertens\u00e3o Arterial","volume":"107","author":"M Malachias","year":"2016","journal-title":"Arq Bras Cardiol"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.fertnstert.2011.08.022","article-title":"Reanalyzing the modified Ferriman-Gallwey score: is there a simpler method for assessing the extent of hirsutism?","volume":"96","author":"H Cook","year":"2011","journal-title":"Fertil Steril"},{"key":"ref27","volume-title":"Diretrizes da Sociedade Brasileira de Diabetes (2015\u20132016)","author":"J EP Oliveira","year":"2016"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/S0004-27302009000200020","article-title":"HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS)","volume":"53","author":"B Geloneze","year":"2009","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"K G Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1477-7827-10-96","article-title":"Polycystic ovary syndrome in Salvador, Brazil: a prevalence study in primary healthcare","volume":"10","author":"L Gabrielli","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"issue":"08","key":"ref31","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/1933719114522525","article-title":"Prevalence of polycystic ovary syndrome phenotypes using updated criteria for polycystic ovarian morphology: an assessment of over 100 consecutive women self-reporting features of polycystic ovary syndrome","volume":"21","author":"N M Clark","year":"2014","journal-title":"Reprod Sci"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-2265.2007.02954.x","article-title":"Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): a prospective study of 634 women with PCOS","volume":"67","author":"E Diamanti-Kandarakis","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1590\/S0004-27302011000100002","article-title":"Dificuldades e armadilhas no diagn\u00f3stico da s\u00edndrome dos ov\u00e1rios polic\u00edsticos","volume":"55","author":"J A Marcondes","year":"2011","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"07","key":"ref34","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1210\/jc.2004-2243","article-title":"Ferriman Gallwey self-scoring I: performance assessment in women with polycystic ovary syndrome","volume":"90","author":"R A Wild","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4067\/S0717-75262010000200009","article-title":"Espectro fenot\u00edpico del s\u00edndrome de ovario poliqu\u00edstico","volume":"75","author":"G R Carvajal","year":"2010","journal-title":"Rev Chil Obstet Ginecol"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.11606\/D.5.2015.tde-27102015-095105","volume-title":"An\u00e1lise Metabol\u00f4mica e Histomorfom\u00e9trica do F\u00edgado de Ratas Adultas em Modelo Experimental da S\u00edndrome dos Ov\u00e1rios Polic\u00edsticos Induzida por Exposi\u00e7\u00e3o Neonatal a Esteroides Sexuais [disserta\u00e7\u00e3o]","author":"A Anzai","year":"2015"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/the-prevalence-of-metabolic-syndrome-in-the-different-phenotypes-of-polycystic-ovarian-syndrome\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1676568.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T16:52:36Z","timestamp":1721321556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/the-prevalence-of-metabolic-syndrome-in-the-different-phenotypes-of-polycystic-ovarian-syndrome\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":36,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,2,4]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1676568","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}