{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:52:57Z","timestamp":1770231177536,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amlodipine has a potential to reduce clopidogrel bioactivation through the cytochrome P450 3A4 enzyme in vivo, but the clinical impact of this interaction remains controversial. This randomized, open-label, two-period, crossover study was performed to evaluate the influence of amlodipine on the haemostatic profiles of high-risk patients during clopidogrel treatment. We recruited 40 Asian patients (Male\/Female: n\u2009=\u200936\/4) receiving clopidogrel (75 mg\/day), aspirin (100 mg\/day) and rosuvastatin for at least 6 months following percutaneous coronary intervention. Patients were randomly assigned to receive either 5\u2009mg daily amlodipine or not for 2 weeks, and then were crossed over to the other treatment for 2 weeks. Haemostatic measurements were conducted with the VerifyNow assay and thromboelastography (TEG). Primary endpoint was P2Y12 Reaction Units (PRU) during on- versus off-amlodipine treatment. The on-amlodipine strategy showed higher level of PRU compared with the off-amlodipine strategy (176.8\u2009\u00b1\u200975.4 vs. 150.7\u2009\u00b1\u200965.5 PRU; \u2206mean: 26.1 PRU; \u220695% confidence interval [CI]: 4.5\u201347.7 PRU; p\u2009=\u20090.019). Platelet-fibrin clot strength measured by TEG was lower during on- versus off-amlodipine treatment (7,712\u2009\u00b1\u20091,889 vs. 8,559\u2009\u00b1\u20092,174 dyne\/cm2; \u2206mean: \u2013847 dyne\/cm2; \u220695% CI: \u20131,632 to \u201362 dyne\/cm2; p\u2009=\u20090.035). After amlodipine discontinuation, 27 patients (67.5%) showed a decrease in PRU, which was associated with \u2018PRU\u2009\u2265\u2009160 on-amlodipine\u2019 in multivariate analysis (odds ratio: 62.014; 95% CI: 2.302\u20131670.328; p\u2009=\u20090.014). In conclusion, amlodipine increases platelet reactivity and decreases platelet-fibrin clot strength during clopidogrel treatment. In addition, the effect of amlodipine discontinuation on clopidogrel responsiveness is associated with on-amlodipine platelet reactivity.<\/jats:p>","DOI":"10.1055\/s-0038-1676795","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T08:36:25Z","timestamp":1547800585000},"page":"264-273","source":"Crossref","is-referenced-by-count":4,"title":["Influence of Amlodipine on Haemostatic Measurements during Clopidogrel Treatment in Patients with Coronary Artery Disease"],"prefix":"10.1055","volume":"119","author":[{"given":"Jin-Sin","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongwhi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Hwa","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Gyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Seok","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Woong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Yoon","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Rang","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok-Jae","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong Hwan","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Yong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya","family":"Tantry","sequence":"additional","affiliation":[{"name":"Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Fairfax, Virginia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Gurbel","sequence":"additional","affiliation":[{"name":"Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Fairfax, Virginia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea"},{"name":"Institute of the Health Sciences, Gyeongsang National University, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,1,4]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1676795.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T21:17:01Z","timestamp":1557177421000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1676795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,1,22]]},"published-print":{"date-parts":[[2019,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1676795","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]}}}