{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:33:09Z","timestamp":1793493189335,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Objective\u2003To review developmental outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH).<\/jats:p>\n                  <jats:p>Study Design\u2003Neonates \u226535 weeks' gestation with mild HIE\/TH (TH group, n\u2009=\u200930) were matched with healthy term-born infants (control group, n\u2009=\u200930) and reviewed for the presence and severity of magnetic resonance imaging (MRI)-detected neurological injury. Neurodevelopmental outcomes were assessed using the Bayley Scales of Infant Development (BSID).<\/jats:p>\n                  <jats:p>Results\u2003MRI injury was present in 13\/30 (43.3%) neonates (11 mild, 1 moderate, and 1 severe injuries) in the TH group. The mean (standard deviation [SD]) corrected age at BSID III was 29.3 (3.9) months in the controls compared with 14.7 (3.9) months in the TH group (p\u2009&lt;\u20090.01). The mean (SD) cognitive, language, and motor composite scores in neonates in the TH group (n\u2009=\u200916, 53.3%) and control groups (n\u2009=\u200930, 100%) were 99.4 (17.1) versus 93.0 (12.3), (p\u2009=\u20090.15), 89.5 (15.5) versus 100.2 (18.4), (p\u2009=\u20090.054), and 93.1 (15.4) versus 100.8 (16.3) (p\u2009=\u20090.13), respectively.<\/jats:p>\n                  <jats:p>Conclusion\u2003Developmental outcomes of neonates with mild HIE\/TH were similar to healthy, term-born neonates.<\/jats:p>","DOI":"10.1055\/s-0038-1676973","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T03:31:42Z","timestamp":1547782302000},"page":"1337-1343","source":"Crossref","is-referenced-by-count":33,"title":["Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia"],"prefix":"10.1055","volume":"36","author":[{"given":"Rakesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamik","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Ann and Robert Laurie School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Distler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Vesoulis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Smyser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit M.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,1,4]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1676973.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T18:31:21Z","timestamp":1572114681000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1676973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":0,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,10,26]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1676973","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]}}}