{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:27:47Z","timestamp":1749796067488},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n            Background\u2003The aim of this retrospective case-control study was to determine the association of vertebral artery hypoplasia (VAH) and other anatomical variants with saccular vertebral artery posterior inferior cerebellar artery (VA-PICA) aneurysms.<\/jats:p><jats:p>\n            Methods\u2003The frequency of VAH, vertebral artery (VA) atresia, VA aplasia, and PICA aplasia was analyzed using computed tomography (CT) angiography in 64 patients with VA-PICA aneurysms (43 ruptured and 21 unruptured) and compared with 128 age- and sex-matched controls. Logistic regression was performed to identify independent risk factors for aneurysm formation.<\/jats:p><jats:p>\n            Results\u2003Univariate analysis showed that patients with VA-PICA aneurysms had a significantly higher frequency of VAH (53% versus 17%; odds ratio [OR] 4.8; 95% confidence interval [CI], 2.4\u20139.4; p\u2009&lt;\u20090.0001) and VA aplasia (14% versus 1%; OR 20.8; 95% CI, 2.5\u2013168.0; p\u2009=\u20090.004) compared with controls. VA-PICA aneurysms are detected significantly more often in the dominant VA, which is contralateral to VAH. Other anatomical variants are not related to aneurysm formation.<\/jats:p><jats:p>\n            Conclusions\u2003VAH and VA aplasia are potential risk factors for VA-PICA aneurysms. Altered hemodynamics caused by VAH may result in intracranial aneurysm formation. Additional research should clarify the pathophysiologic association of VAH, VA aplasia, or vascular occlusion with arteriosclerosis and intracranial aneurysm formation.<\/jats:p>","DOI":"10.1055\/s-0038-1677453","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T22:43:35Z","timestamp":1562280215000},"page":"365-370","source":"Crossref","is-referenced-by-count":3,"title":["Association between Vertebral Artery Hypoplasia and Vertebral Artery Aneurysms: A Case-Control Study"],"prefix":"10.1055","volume":"80","author":[{"given":"Ali","family":"Harati","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum Dortmund, Dortmund, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Zeh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum Dortmund, Dortmund, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum Dortmund, Dortmund, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Schulthei\u00df","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum Dortmund, Dortmund, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Knappschaftskrankenhaus Bochum, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Hernesniemi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juha Hernesniemi International Center, Henan Province People's Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,7,4]]},"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1677453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T23:12:46Z","timestamp":1566342766000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1677453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2019,8,20]]},"published-print":{"date-parts":[[2019,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1677453","relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,4]]}}}