{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:01Z","timestamp":1740126781276,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2015-0578"],"award-info":[{"award-number":["2015-0578"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1\u03b2, IL-6, IL-8, IL-10, IFN-\u03b3 [interferon-\u03b3 ], MCP-1 [monocyte chemoattractant protein-1], MIP-1\u03b2 [macrophage inflammatory protein-1\u03b2], and TNF-\u03b1 [tumor necrosis factor-\u03b1]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R\u2009+\u2009W\u2009+\u2009). Among the 24 patients without WMI, 11 were infected with rotavirus (R\u2009+\u2009W\u2009\u2212\u2009) and 13 were not (R\u2009\u2212\u2009W\u2009\u2212\u2009).Only MCP-1 and MIP-1\u03b2 were different between the groups. MCP-1 was increased in R+ W+ compared with R\u2009+\u2009W\u2212 (p\u2009&lt;\u20090.01), R\u2009\u2212\u2009W\u2212 (p\u2009&lt;\u20090.01), and control (p\u2009=\u20090.03) patients. MIP-1\u03b2 was decreased in R\u2009+\u2009W+ compared with R\u2009\u2212\u2009W\u2212 (p\u2009&lt;\u20090.01) and control (p\u2009&lt;\u20090.01), but not R\u2009+\u2009W\u2212 (p\u2009=\u20090.23) patients. MCP-1 and MIP-1\u03b2 are C-C chemokines that recruit immune cells to the site of inflammation. Our pilot study suggests MCP-1-mediated monocyte recruitment may be linked with this complication caused by rotavirus.<\/jats:p>","DOI":"10.1055\/s-0038-1677516","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T19:35:52Z","timestamp":1554233752000},"page":"228-234","source":"Crossref","is-referenced-by-count":2,"title":["Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns"],"prefix":"10.1055","volume":"50","author":[{"given":"Jung Sook","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Young","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hee","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang-Ok","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Shang","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Hoo","family":"Park","sequence":"additional","affiliation":[{"name":"Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea"},{"name":"Department of Pediatrics, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,4,2]]},"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1677516.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T18:39:06Z","timestamp":1563302346000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1677516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,7,16]]},"published-print":{"date-parts":[[2019,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1677516","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"type":"print","value":"0174-304X"},{"type":"electronic","value":"1439-1899"}],"subject":[],"published":{"date-parts":[[2019,4,2]]}}}