{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:29:41Z","timestamp":1758810581341,"version":"3.44.0"},"reference-count":0,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Genet"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the relationship of two single nucleotide polymorphisms (SNPs) in the interleukin-18 (IL18) gene (rs187238, g.-137G\u2009&gt;\u2009C; rs1946518, g.-607C\u2009&gt;\u2009A) and one SNP of the IL12B gene (rs3212227 g.*159A\u2009&gt;\u2009C, 3\u2032UTR) with the age of onset for type 1 diabetes mellitus (DM1). A total of 1,101 patients with DM1 enrolled in 13 centers from different regions of Brazil were genotyped with TaqMan assay and classified according to the ancestry. Our results show that an SNP in IL18 gene could be associated with DM1 age onset, taking into account that this studied variation affects gene expression.<\/jats:p>","DOI":"10.1055\/s-0039-1677749","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T19:10:58Z","timestamp":1548875458000},"page":"038-040","source":"Crossref","is-referenced-by-count":2,"title":["IL18 Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians"],"prefix":"10.53391","volume":"08","author":[{"given":"Alejandro","family":"Bo\u00ebchat-Fernandes","sequence":"first","affiliation":[{"name":"Department of Genetics, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e2ngela","family":"R\u00e9a","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Service, University Hospital of the Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Romanzini","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Service, University Hospital of the Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia","family":"Gomes","sequence":"first","affiliation":[{"name":"Diabetes Unit, Department of Internal Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lupe","family":"Furtado-Alle","sequence":"first","affiliation":[{"name":"Department of Genetics, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Genetics, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2019,1,30]]},"container-title":["Journal of Pediatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1677749.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:45:38Z","timestamp":1758138338000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1677749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,30]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,2,14]]},"published-print":{"date-parts":[[2019,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1677749","relation":{},"ISSN":["2146-4596","2146-460X"],"issn-type":[{"type":"print","value":"2146-4596"},{"type":"electronic","value":"2146-460X"}],"subject":[],"published":{"date-parts":[[2019,1,30]]}}}