{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:06:52Z","timestamp":1791893212595,"version":"4.3.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Background\u2003The optimal first line treatment for patients with isolated superficial venous thrombosis (SVT) of the lower extremity is unknown.<\/jats:p>\n                  <jats:p>Objective\u2003This article reports estimates of the rate of venous thromboembolic complications among patients with SVT according to treatment.<\/jats:p>\n                  <jats:p>Materials and Methods\u2003A systematic review and meta-analysis was performed using unrestricted searches of electronic databases. Reported events were transformed to event per 100 patient-years of follow-up and a random effects model was used to calculate pooled rates according to pre-specified treatment categories. The primary outcome was the occurrence of deep vein thrombosis (DVT) or pulmonary embolism (PE) during the study follow-up period.<\/jats:p>\n                  <jats:p>Results\u2003Seventeen articles, including 6,862 patients, were included in the meta-analysis. Fondaparinux had the lowest event rate with 1.4 events per 100 patient-years of follow-up (95% confidence interval [CI], 0.5\u20132.8, I\n            2\u2009=\u200918%). Pooled event rates for DVT or PE ranged from 9.3 to 16.6 events per 100 patient-years across other treatment categories, and the pooled event rate for no treatment\/placebo was 10.5 events per 100 patient-years (95% CI, 3.0\u201322.0). Major bleeding was low and similar across all treatment categories. Heterogeneity was moderate to high for most pooled estimates.<\/jats:p>\n                  <jats:p>Conclusion\u2003While pooled event rates suggest that fondaparinux achieves the lowest rate of DVT or PE, low-quality evidence for other treatments prevents firm conclusions about the optimal treatment for SVT.<\/jats:p>","DOI":"10.1055\/s-0039-1677793","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T18:56:29Z","timestamp":1549306589000},"page":"479-489","source":"Crossref","is-referenced-by-count":52,"title":["Treatment of Superficial Vein Thrombosis: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"119","author":[{"given":"Lisa","family":"Duffett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Kearon","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Rodger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Carrier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,2,4]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1677793.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:20:47Z","timestamp":1557163247000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1677793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,2,25]]},"published-print":{"date-parts":[[2019,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1677793","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]}}}