{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:59:13Z","timestamp":1761490753386},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To date, few studies have investigated whether perinatal factors affect coagulation parameters at birth in preterm and term neonates. We retrospectively investigated coagulation factors on day 1 in 609 consecutive neonates admitted to our neonatal intensive care unit between January 2010 and December 2017. We measured coagulation factors on day 1 using peripheral blood samples. Multivariate analysis revealed that prothrombin time\u2013international normalized ratio correlated with intraventricular hemorrhage (p\u2009=\u20090.000; \u03b2\u2009=\u20090.180) and placental abruption (PA; p\u2009=\u20090.000; \u03b2\u2009=\u20090.142). Activated partial thromboplastin time (aPTT) correlated with birth weight (BW; p\u2009=\u20090.000; \u03b2\u2009=\u2009\u2009\u2212\u20090.217), gestational age (GA; p\u2009=\u20090.000; \u03b2\u2009=\u2009\u2009\u2212\u20090.282), and PA (p\u2009=\u20090.000; \u03b2\u2009=\u20090.181). Fibrinogen concentration was associated with respiratory distress syndrome (p\u2009=\u20090.007; \u03b2\u2009=\u2009\u2009\u2212\u20090.114), pregnancy-induced hypertension (p\u2009=\u20090.000; \u03b2\u2009=\u2009\u2009\u2212\u20090.141), and Apgar score at 1 minute (p\u2009=\u20090.043; \u03b2\u2009=\u20090.147). Furthermore, the level of d-dimer inversely correlated with Apgar score at 5 minutes (p\u2009=\u20090.049). Finally, antithrombin III levels positively correlated with GA (p\u2009=\u20090.000) and BW (p\u2009=\u20090.000). Thus, maternal and neonatal complications affect coagulation parameters in preterm and term neonates.<\/jats:p>","DOI":"10.1055\/s-0039-1677867","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T23:39:22Z","timestamp":1548977962000},"page":"1464-1470","source":"Crossref","is-referenced-by-count":6,"title":["Perinatal Factors Affecting Coagulation Parameters at Birth in Preterm and Term Neonates: A Retrospective Cohort Study"],"prefix":"10.1055","volume":"36","author":[{"given":"Hayato","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ohto","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Nollet","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Kashiwabara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Chishiki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Momoi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,1,31]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1677867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T15:41:46Z","timestamp":1576251706000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1677867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,31]]},"references-count":0,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2019,11,28]]},"published-print":{"date-parts":[[2019,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1677867","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,31]]}}}