{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T05:12:40Z","timestamp":1722402760419},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n            Objective\u2003In countries with low factor concentrate consumption, disabling joint disease remains the major morbidity in patients with haemophilia. The objective of the present analysis is to express the trend and profile of invasive orthopaedic interventions in our country with low usage of factor replacement, lacking the prophylaxis program until recent years.<\/jats:p><jats:p>\n            Patients and Methods\u2003This retrospective descriptive study was conducted in our university centre in Timisoara with long-lasting experience in haemophilia care, which succeeded in developing an exceptionally valuable genuine comprehensive inter-institutional cooperation. This study refers to 115 invasive interventions performed on 97 patients: 83 with haemophilia A, 10 with haemophilia B and 4 with von Willebrand disease in the period of 2001 to 2017; 17 of them had inhibitors, 5 developing inhibitors after the intervention.<\/jats:p><jats:p>\n            Results and Discussion\u2003The cohort of patients consisted mostly of young adults, aged between 7 and 49 years. The vast majority of them, 91.3% of the patients, had the burden of severe chronic arthropathy. This was the reason for 95 interventions, with programmed solution. In 20 cases the cause of invasive interventions was emergency. Knee and hip replacement represented 28% of the major interventions. The complications we encountered were excessive bleeding (12.2%), infection (13%) and inhibitor development (4.3%).<\/jats:p><jats:p>\n            Conclusion\u2003Surgery is a demanding intervention in patients with haemophilia, which unfortunately cannot be ignored in our country. Hopefully, the improved availability and accessibility to replacement therapy will eliminate the necessity of these interventions, optimizing the outcomes for the next generations.<\/jats:p>","DOI":"10.1055\/s-0039-1677884","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:18:45Z","timestamp":1550103525000},"page":"377-382","source":"Crossref","is-referenced-by-count":1,"title":["Current Trend of Invasive Orthopaedic Interventions for People with Haemophilia in Romania: Single Centre Experience"],"prefix":"10.1055","volume":"39","author":[{"given":"Margit","family":"Serban","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, Emergency Children's Hospital \u201cLouis Turcanu,\u201d European Haemophilia Treatment Center, Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan Vasile","family":"Poenaru","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenel Marian","family":"Patrascu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislau","family":"Ritli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato-Oncology, University of Medicine and Pharmacy, County Hospital, Oradea, Bihor, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Boia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia Maria","family":"Mihailov","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Emilia","family":"Ursu","sequence":"additional","affiliation":[{"name":"Department of Hemato-Oncology, Emergency Children's Hospital \u201cLouis Turcanu,\u201d European Haemophilia Treatment Center, Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Savescu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Children's Emergency Hospital \u201cLouis Turcanu,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ionita","sequence":"additional","affiliation":[{"name":"Department of Hematology, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina","family":"Traila","sequence":"additional","affiliation":[{"name":"European Hemophilia Treatment Center, Medical Center for Children and adolescents \u201cC. Serban\u201d Buzias, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Cerbu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estera","family":"Boeriu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato-Oncology, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Jinca","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato-Oncology, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schramm","sequence":"additional","affiliation":[{"name":"Rudolf Marx Stiftung Bluterbetreuung Bayern e. V. (BBB) - Universit\u00e4t M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaranda","family":"Arghirescu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato-Oncology, University of Medicine and Pharmacy \u201cVictor Babes,\u201d Timisoara, Timis, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,2,13]]},"container-title":["H\u00e4mostaseologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1677884.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T06:06:50Z","timestamp":1574316410000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1677884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,11,20]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1677884","relation":{},"ISSN":["0720-9355","2567-5761"],"issn-type":[{"value":"0720-9355","type":"print"},{"value":"2567-5761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]}}}