{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:20:11Z","timestamp":1781590811387,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n            Objective\u2003Methemoglobinemia (MetHb) is a rare congenital or acquired cause of infantile cyanosis. We examined the role of MetHb in a neonatal intensive care unit (NICU).<\/jats:p><jats:p>\n            Study Design\u2003A retrospective observational study was conducted reviewing blood gas analyses of hospitalized newborns over a 2-year period. MetHb-positive patients (MetHb &gt;1.8%) were matched with a control group for gestational age, weight, disease, and illness severity at admission. Maternal, neonatal, clinical, and laboratory parameters were collected and analyzed in both groups.<\/jats:p><jats:p>\n            Results\u2003MetHb incidence was 6%. The mean MetHb in the case group was 7.2%, and the first positive samples were observed at a mean of 22 days of life, 6 days prior to clinical or culture-proven sepsis. We identified low maternal age (31 vs. 34 years; p\u2009=\u20090.038), sepsis (90 vs. 45%; p\u2009=\u20090.022), and protracted parenteral nutrition (46 vs. 23 days; p\u2009=\u20090.013) as risk factors for MetHb, and early minimal enteral feeding as protective factor (12th vs. 9th day; p\u2009=\u20090.038).<\/jats:p><jats:p>\n            Conclusion\u2003MetHb has a high occurrence in NICU and can be a helpful prognostic indicator of an infectious process. Understanding and prompt identification of MetHb can allow pediatricians to implement a life-saving therapy.<\/jats:p>","DOI":"10.1055\/s-0039-1678556","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:18:46Z","timestamp":1549066726000},"page":"1510-1513","source":"Crossref","is-referenced-by-count":11,"title":["Methemoglobinemia Associated with Late-Onset Neonatal Sepsis: A Single-Center Experience"],"prefix":"10.1055","volume":"36","author":[{"given":"Ingrid Anne Mandy","family":"Schierz","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, AOUP \u201cP. Giaccone,\u201d Department of Sciences for Health Promotion and Mother and Child Care \u201cG. D'Alessandro,\u201d University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Pinello","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, AOUP \u201cP. Giaccone,\u201d Department of Sciences for Health Promotion and Mother and Child Care \u201cG. D'Alessandro,\u201d University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Piro","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, AOUP \u201cP. Giaccone,\u201d Department of Sciences for Health Promotion and Mother and Child Care \u201cG. D'Alessandro,\u201d University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Giuffr\u00e8","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, AOUP \u201cP. Giaccone,\u201d Department of Sciences for Health Promotion and Mother and Child Care \u201cG. D'Alessandro,\u201d University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Corsello","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, AOUP \u201cP. Giaccone,\u201d Department of Sciences for Health Promotion and Mother and Child Care \u201cG. D'Alessandro,\u201d University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,2,1]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1678556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T15:41:55Z","timestamp":1576251715000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1678556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":0,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2019,11,28]]},"published-print":{"date-parts":[[2019,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1678556","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]}}}