{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:55Z","timestamp":1790643835897,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>\n            Objective\u2003Pulmonary hypertension with left ventricular dysfunction commonly occurs in congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-III inhibitor with lusitropic and vasodilator effects, is used in up to 30% of CDH infants across the United States. No randomized trials have tested the efficacy or safety of milrinone in CDH neonates.<\/jats:p><jats:p>\n            Study Design\u2003We performed a paired retrospective analysis of CDH infants to assess the efficacy of milrinone treatment (N\u2009=\u200924 pairs). Efficacy was assessed by change in oxygenation index (OI) and calculated pulmonary artery pressure (PAP). We evaluated safety on the basis of risks factors such as nonoperative bleeding, dysrhythmia, hypokalemia, and thrombocytopenia.<\/jats:p><jats:p>\n            Results\u2003The median age of milrinone initiation was 18 hours (interquartile range [IQR]: 9\u201338) and the median duration was 127 hours (IQR: 95\u2013194). PAP did not change from the baseline of 49\u2009\u00b1\u200911\u2009mm Hg (milrinone) and 53\u2009\u00b1\u200911\u2009mm Hg (no milrinone; p\u2009=\u20090.327). Baseline OI was 9.6\u2009\u00b1\u20096.5. There was a similar decrease in OI (median [IQR]; milrinone: 58% [16\u201374]; vs. no milrinone: 65% [50\u201371]; p\u2009=\u20090.221 between groups; p\u2009&lt;\u20090.005 within groups). Baseline left ventricle measurements were similar. Both groups showed significant improvement over time. No adverse events were noted.<\/jats:p><jats:p>\n            Conclusion\u2003In OI-matched untreated neonates with mild-to-moderate CDH, milrinone use was associated with neither improved OI, PAP, or left ventricular measurements, nor adverse events. Study limitations warrant prospective randomized controlled trials.<\/jats:p>","DOI":"10.1055\/s-0039-1678558","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:18:46Z","timestamp":1549066726000},"page":"258-263","source":"Crossref","is-referenced-by-count":14,"title":["Is Milrinone Effective for Infants with Mild-to-Moderate Congenital Diaphragmatic Hernia?"],"prefix":"10.1055","volume":"37","author":[{"given":"Michelle","family":"Mears","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Utah School of Medicine, Salt Lake City, Utah"},{"name":"Division of Neonatology, Primary Children's Hospital, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Primary Children's Hospital, Salt Lake City, Utah"},{"name":"Division of Neonatology, University of Utah School of Medicine, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Primary Children's Hospital, Salt Lake City, Utah"},{"name":"Division of Neonatology, University of Utah School of Medicine, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,2,1]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1678558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T23:36:59Z","timestamp":1582069019000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1678558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,2,18]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1678558","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]}}}