{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:48:41Z","timestamp":1789595321986,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>\n            Objective\u2003To assess the effect of range-of-motion exercise program on bone mineralization and somatic growth of very low birth weight (VLBW) infants.<\/jats:p><jats:p>\n            Study Design\u2003A total of 36 VLBW infants were randomized into 18 VLBW infants receiving range-of-motion exercise and 18 VLBW control infants receiving tactile stimulation for 4 weeks. Laboratory investigations were performed at baseline and postexercise and included serum calcium, serum phosphorus (s.PO4), magnesium, alkaline phosphatase (ALP), urinary calcium\/phosphate ratio, and serum carboxy-terminal cross-linked telopeptide of type 1 collagen (CTX). Dual-energy X-ray absorptiometry was performed at the end of the exercise protocol to measure bone mineral content, bone mineral density (BMD), bone area, lean mass, and fat mass.<\/jats:p><jats:p>\n            Results\u2003The weight and the rate of weight gain were significantly higher (p\u2009&lt;\u20090.001) in the exercise group compared with controls postexercise. Also, higher s.PO4, lower ALP, and lower urinary calcium\/phosphate ratio were observed postexercise in the exercise group (p\u2009=\u20090.001, p\u2009=\u20090.005, and p\u2009=\u20090.04, respectively), whereas serum CTX showed no difference between the two groups (p\u2009=\u20090.254). Postexercise BMD significantly improved in the exercise group (p\u2009&lt;\u20090.001) compared with controls.<\/jats:p><jats:p>\n            Conclusion\u2003Although the sample size was small, we may be able to suggest favorable effects of range-of-motion exercise versus tactile stimulation on bone metabolism, BMD, and short-term growth in VLBW infants.<\/jats:p>","DOI":"10.1055\/s-0039-1678559","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T23:45:08Z","timestamp":1549583108000},"page":"313-321","source":"Crossref","is-referenced-by-count":4,"title":["Passive Range-of-Motion Exercise and Bone Mineralization in Preterm Infants: A Randomized Controlled Trial"],"prefix":"10.1055","volume":"37","author":[{"given":"Rania A.","family":"El-Farrash","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim S.","family":"Abo-Seif","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer K.","family":"El-Zohiery","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan M.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham M.","family":"Abulfadl","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Maternity Hospital, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,2,7]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1678559.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T23:37:14Z","timestamp":1582069034000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1678559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,2,18]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1678559","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]}}}