{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T05:41:48Z","timestamp":1670046108095},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n            Aim\u2003This study was designed to investigate how the asymmetry of the brain stem is related to hand function and manual ability after arterial ischemic stroke (AIS) diagnosed during childhood.<\/jats:p><jats:p>\n            Method\u2003Patients diagnosed with AIS during childhood (&gt; 5 years old, diagnosis\u2009&gt;\u20092 years before recruitment) and typically developing peers were recruited by the Swiss Neuropediatric Stroke Registry. Brainstem cross-sectional areas of each side at the level of the pons were measured. Pinch and grip strength were measured with a dynamometer, quality of upper limb movement by the Melbourne Assessment 2 and manual ability by the ABILHAND-kids. An asymmetry index was calculated for all measures (except the ABILHAND-kids). Differences between groups and correlations were calculated using nonparametric statistics.<\/jats:p><jats:p>\n            Results\u2003Fourteen AIS survivors without hemiparesis, 10 AIS survivors with hemiparesis, and 47 typically developing peers were assessed. Patients with hemiparesis showed the highest brainstem asymmetry. There was a significant positive correlation between brainstem asymmetry, the asymmetry of strength and quality of upper limb movement, and a significant negative correlation between brainstem asymmetry and manual ability.<\/jats:p><jats:p>\n            Interpretation\u2003In pediatric AIS survivors, brainstem asymmetry can serve as an indirect measure of corticospinal tract integrity. It is significantly correlated with strength, quality of movement, and manual ability.<\/jats:p>","DOI":"10.1055\/s-0039-1678610","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T23:54:39Z","timestamp":1549410879000},"page":"138-145","source":"Crossref","is-referenced-by-count":4,"title":["Is Asymmetry of the Pons Associated with Hand Function and Manual Ability after Arterial Ischemic Stroke in Children?"],"prefix":"10.1055","volume":"50","author":[{"given":"Nedelina","family":"Slavova","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Neuroradiology, University Hospital, Inselspital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Shojai","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, University Children's Hospital, Bern University Hospital, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regula","family":"Everts","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, University Children's Hospital, Bern University Hospital, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Wiest","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Neuroradiology, University Hospital, Inselspital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Steinlin","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, University Children's Hospital, Bern University Hospital, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Grunt","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, University Children's Hospital, Bern University Hospital, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,2,5]]},"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1678610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T22:44:46Z","timestamp":1557873886000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1678610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,5,14]]},"published-print":{"date-parts":[[2019,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1678610","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"value":"0174-304X","type":"print"},{"value":"1439-1899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]}}}