{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:32:33Z","timestamp":1761060753613,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n            Introduction\u2003Cerebral micro-embolic signals (MES) predict risk of stroke in carotid stenosis patients. However, MES-negative \u2018recently symptomatic patients\u2019 also have a higher stroke risk than \u2018asymptomatic patients\u2019. Differences in platelet activation status may contribute to this disparity in risk.<\/jats:p><jats:p>\n            Methods\u2003This prospective, observational study assessed platelet biomarkers and their relationship with MES in asymptomatic versus symptomatic moderate (\u226550\u201369%) or severe (\u226570\u201399%) carotid stenosis patients. Full blood count parameters were measured and whole-blood flow cytometry was used to quantify platelet surface CD62P and CD63 expression and leucocyte\u2013platelet complex formation. Bilateral simultaneous transcranial Doppler ultrasound of the middle cerebral arteries classified patients as \u2018MES positive\u2019 or \u2018MES negative\u2019.<\/jats:p><jats:p>\n            Results\u2003Data from 34 asymptomatic patients were compared with those from 43 symptomatic patients in the \u2018early phase\u2019 (\u2264\u20094 weeks) and 37 of these symptomatic patients in the \u2018late phase\u2019 (\u2265\u20093 months) after transient ischaemic attack\/ischaemic stroke. There were no differences in %CD62P or %CD63 expression between early or late symptomatic and asymptomatic patients overall (p\u2009&gt;\u20090.05). The percentage of lymphocyte\u2013platelet complexes was higher in early symptomatic than in asymptomatic patients (2.8 vs. 2.16%; p\u2009&lt;\u20090.001). MES were more commonly observed in early symptomatic (31.4%; p\u2009=\u20090.027) but not in late symptomatic (6.7%; p\u2009=\u20090.996) versus asymptomatic patients (7.1%). The percentage of lymphocyte\u2013platelet complexes was higher in early symptomatic than in asymptomatic MES-negative patients (2.7 vs. 2.17%; p\u2009=\u20090.02).<\/jats:p><jats:p>\n            Conclusion These data add to the evidence that leucocyte\u2013platelet complex formation\/platelet activation is increased in recently symptomatic versus asymptomatic patients, and may contribute to the pathogenesis of first and subsequent strokes in carotid stenosis patients, including those who are MES negative.<\/jats:p>","DOI":"10.1055\/s-0039-1678666","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T19:57:31Z","timestamp":1550260651000},"page":"821-833","source":"Crossref","is-referenced-by-count":6,"title":["Increased Leucocyte\u2013Platelet Complex Formation in Recently Symptomatic versus Asymptomatic Carotid Stenosis Patients and in Micro-emboli Negative Subgroups"],"prefix":"10.1055","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-2087","authenticated-orcid":false,"given":"Stephen","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Stroke Service, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Stroke Service, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Kinsella","sequence":"additional","affiliation":[{"name":"Department of Neurology, St Vincent\u2019s University Hospital, University College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Tierney","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Feeley","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Dublin Midlands Hospital Group, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Collins","sequence":"additional","affiliation":[{"name":"Stroke Service, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Stroke Service, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Stroke Service, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Harbison","sequence":"additional","affiliation":[{"name":"Department of Medicine for the Elderly\/Stroke Service, St James Hospital\/Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St James Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St James Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Colgan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St James Hospital\/Trinity College Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dermot","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Department of Surgery, Royal Free Hampstead NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Stroke Service, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Age-Related Health Care Department, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Vascular Neurology Research Foundation, c\/o Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)\/Tallaght University Hospital, Dublin, Ireland"},{"name":"Department of Clinical Neurosciences, Royal Free Campus, UCL Institute of Neurology, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,2,15]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1678666.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T17:28:09Z","timestamp":1557163689000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1678666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2019,5,2]]},"published-print":{"date-parts":[[2019,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1678666","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"type":"print","value":"0340-6245"},{"type":"electronic","value":"2567-689X"}],"subject":[],"published":{"date-parts":[[2019,2,15]]}}}