{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:01:50Z","timestamp":1775199710538,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"rEVO Biologics Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n            Objective\u2003The burden of preeclampsia severity on the health of mothers and infants during the first year after delivery is unclear, given the lack of population-based longitudinal studies in the United States.<\/jats:p><jats:p>\n            Study design\u2003We assessed maternal and infant adverse outcomes during the first year after delivery using population-based hospital discharge information merged with vital statistics and birth certificates of 2,021,013 linked maternal\u2013infant births in California. We calculated sampling weights using the National Center for Health Statistics data to adjust for observed differences in maternal characteristics between California and the rest of the United States. Separately, we estimated the association between preeclampsia and gestational age and examined collider bias in models of preeclampsia and maternal and infant adverse outcomes.<\/jats:p><jats:p>\n            Results\u2003Compared with women without preeclampsia, women with mild and severe preeclampsia delivered 0.66 weeks (95% confidence interval [CI]: 0.64, 0.68) and 2.74 weeks (95% CI: 2.72, 2.77) earlier, respectively. Mild preeclampsia was associated with an increased risk of having any maternal adverse outcome (relative risk [RR]\u2009=\u20091.95; 95% CI: 1.93, 1.97), as was severe preeclampsia (RR\u2009=\u20092.80; 95% CI: 2.78, 2.82). The risk of an infant adverse outcome was increased for severe preeclampsia (RR\u2009=\u20092.15; 95% CI: 2.14, 2.17) but only marginally for mild preeclampsia (RR\u2009=\u20090.99; 95% CI: 0.98, 1). Collider bias produced an inverse association for mild preeclampsia and attenuated the association for severe preeclampsia in models for any infant adverse outcome.<\/jats:p><jats:p>\n            Conclusion\u2003Using multiple datasets, we estimated that severe preeclampsia is associated with a higher risk of maternal and infant adverse outcomes compared with mild preeclampsia, including an earlier preterm delivery.<\/jats:p>","DOI":"10.1055\/s-0039-1679916","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T23:50:06Z","timestamp":1550620206000},"page":"398-408","source":"Crossref","is-referenced-by-count":22,"title":["Maternal and Infant Adverse Outcomes Associated with Mild and Severe Preeclampsia during the First Year after Delivery in the United States"],"prefix":"10.1055","volume":"37","author":[{"given":"Thanh G.N.","family":"Ton","sequence":"additional","affiliation":[{"name":"Precision Health Economics, Oakland, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko V.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin","family":"Incerti","sequence":"additional","affiliation":[{"name":"Precision Health Economics, Oakland, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desi","family":"Peneva","sequence":"additional","affiliation":[{"name":"Precision Health Economics, Oakland, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Druzin","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Stevens","sequence":"additional","affiliation":[{"name":"PAREXEL International, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Butwick","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,2,19]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1679916.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T23:48:12Z","timestamp":1583365692000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1679916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,19]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,3,4]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1679916","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,19]]}}}