{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:28:37Z","timestamp":1762507717669,"version":"3.37.3"},"reference-count":12,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"04","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n            Background\u2003Most endometrial cancers (75%) are diagnosed in early stages (stages I and II), in which abnormal uterine bleeding is the most frequent clinical sign. When the diagnosis is performed in stage IV, the most common sites of metastasis are the lungs, liver and bones. Central nervous system (CNS) metastasis is a rare condition. The aim of this study is to describe a case of uterine papillary serous adenocarcinoma of the endometrium that progressed to brain and bone metastases.<\/jats:p><jats:p>\n            Case Report\u2003We present the case of a 56-year-old woman with abnormal uterine bleeding and endometrial thickened echo (1.8 cm). A hysteroscopy with biopsy was performed, which identified poor differentiated serous adenocarcinoma of the endometrium. A total abdominal hysterectomy, with pelvic and para-aortic lymphadenectomy, was performed. Analysis of the surgical specimen revealed a grade III uterine papillary serous adenocarcinoma. Adjuvant radio\/chemotherapy (carboplatin and paclitaxel\u2014six cycles) was indicated. Sixteen months after the surgery, the patient began to complain of headaches. Brain magnetic resonance imaging demonstrated an expansile mass in the right parietal lobe, suggesting a secondary hematogenous implant subsequently confirmed by biopsy. She underwent surgery for treatment of brain metastasis, followed by radiotherapy. She died 12 months after the brain metastasis diagnosis due to disease progression.<\/jats:p><jats:p>\n            Conclusion\u2003Uterine papillary serous adenocarcinoma of the endometrium has a low propensity to metastasize to the brain. To the best of our knowledge, this is the fifth documented case of uterine papillary serous adenocarcinoma of the endometrium with metastasis to the CNS.<\/jats:p>","DOI":"10.1055\/s-0039-1683353","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T23:46:09Z","timestamp":1555458369000},"page":"264-267","source":"Crossref","is-referenced-by-count":3,"title":["Brain Metastasis in Papillary Serous Adenocarcinoma of the Endometrium"],"prefix":"10.61622","volume":"41","author":[{"given":"Walberto Monteiro Neiva","family":"Eul\u00e1lio Filho","sequence":"additional","affiliation":[{"name":"Department of Specialized Medicine, Universidade Federal do Piau\u00ed, Teresina, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u00edla Sousa de Moura","family":"F\u00e9","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Uninovafapi, Teresina, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-7846","authenticated-orcid":false,"given":"Rodolfo Myronn de Melo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Specialized Medicine, Universidade Federal do Piau\u00ed, Teresina, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Simone Oliveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Specialized Medicine, Universidade Federal do Piau\u00ed, Teresina, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabas Carlos","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Specialized Medicine, Universidade Federal do Piau\u00ed, Teresina, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.rard.2017.05.005","article-title":"Consenso Nacional Intersociedades sobre C\u00e1ncer de Endometrio","volume":"81","year":"2017","journal-title":"Rev Argent Radiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(15)00130-0","article-title":"Endometrial cancer","volume":"387","author":"P Morice","year":"2016","journal-title":"Lancet"},{"key":"ref4","first-page":"467","article-title":"[Uterine papillary serous and clear cell carcinoma]. Prog","volume":"50","author":"A E Urdampilleta","year":"2007","journal-title":"Obstet Ginecol (Bucur)"},{"issue":"06","key":"ref5","first-page":"549","article-title":"[Metastatic mechanisms of uterine malignancies and therapeutic consequences]","volume":"37","author":"S F Lax","year":"2016","journal-title":"Pathologe"},{"issue":"01","key":"ref6","first-page":"249","article-title":"Is endometrial cancer really a neurophobic tumor? A case report and review of the literature","volume":"34","author":"M Nassir","year":"2014","journal-title":"Anticancer Res"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ygyno.2016.04.013","article-title":"Primary brain metastases of endometrial cancer: A report of 18 cases and review of the literature","volume":"142","author":"S Uccella","year":"2016","journal-title":"Gynecol Oncol"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3171\/jns.2001.94.5.0846","article-title":"Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer. Report of two cases and review of the literature","volume":"94","author":"E Petru","year":"2001","journal-title":"J Neurosurg"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ygyno.2004.02.006","article-title":"Brain metastases from endometrial carcinoma: a retrospective study","volume":"93","author":"L T Gien","year":"2004","journal-title":"Gynecol Oncol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ygyno.2007.05.027","article-title":"Multimodal therapy improves survival in patients with CNS metastasis from uterine cancer: a retrospective analysis and literature review","volume":"107","author":"J C Chura","year":"2007","journal-title":"Gynecol Oncol"},{"key":"ref11","first-page":"581749","article-title":"Brain metastases from endometrial carcinoma","volume":"2012","author":"E Piura","year":"2012","journal-title":"ISRN Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.34024\/rnc.2001.v9.8929","article-title":"Met\u00e1stases cerebrais","volume":"9","author":"A J Santos","year":"2001","journal-title":"Rev Neuroci\u00eanc."},{"key":"ref13","first-page":"68","article-title":"[Brain metastasis of endometrial cancer: report of a case and review of literature]","volume":"20","author":"F Kouhen","year":"2015","journal-title":"Pan Afr Med J"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/brain-metastasis-in-papillary-serous-adenocarcinoma-of-the-endometrium\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1683353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:57:47Z","timestamp":1721336267000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/brain-metastasis-in-papillary-serous-adenocarcinoma-of-the-endometrium\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":12,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,5,2]]},"published-print":{"date-parts":[[2019,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1683353","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"type":"print","value":"0100-7203"},{"type":"electronic","value":"1806-9339"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}