{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:58:31Z","timestamp":1791496711528,"version":"4.3.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Introduction\u2003Atrial fibrillation (AF) is associated with dementia. Anticoagulation may modify this relationship, but it is unclear if this is due to stroke reduction alone.<\/jats:p>\n                  <jats:p>Methods\u2003Age- and sex-matched individuals from the U.K. Clinical Practice Research Datalink (2008\u20132016) with and without an incident diagnosis of AF were followed for a new dementia diagnosis. We estimated adjusted hazard ratios (aHRs) for incident dementia diagnosis in the AF cohort, overall and stratified by anticoagulation status, using the matched non-AF cohorts as reference. We performed a sensitivity analysis excluding individuals with stroke\/transient ischaemic attack (TIA) before the observation period.<\/jats:p>\n                  <jats:p>Results\u2003Over 193,082 person-years (mean follow-up 25.7\u2009\u00b1\u20090.1 months), 347\/15,276 AF (2.3%) and 1,085\/76,096 non-AF (1.4%) were newly diagnosed with dementia (aHR, 1.31, 95% confidence interval, 1.15\u20131.49). The AF group had more co-morbidity and higher rates of dementia, both with and without anticoagulation, than non-AF. When those with history of stroke\/ TIA before the observation period were excluded and those with incident stroke\/TIA during the observation period were censored, AF individuals not on anticoagulation had significantly higher rates of dementia compared with non-AF, aHR 1.30 (1.06\u20131.58).<\/jats:p>\n                  <jats:p>Conclusion\u2003Our findings support the hypothesis that AF is a distinct risk factor for dementia, independent of stroke\/TIA and other vascular risk factors. In those without stroke\/TIA, risk of dementia is increased only in those who are not on anticoagulation, suggesting anticoagulation is protective presumably through reduction of sub-clinical embolic events. Further prospective research is needed to better ascertain the role of anticoagulation amongst targeted therapeutic strategies to reduce cognitive decline in AF.<\/jats:p>","DOI":"10.1055\/s-0039-1683429","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T20:14:52Z","timestamp":1553717692000},"page":"981-991","source":"Crossref","is-referenced-by-count":39,"title":["Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study"],"prefix":"10.1055","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-0633","authenticated-orcid":false,"given":"Thalia S.","family":"Field","sequence":"additional","affiliation":[{"name":"Division of Neurology, Vancouver Stroke Program, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Weijs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Curcio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Giustozzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universit\u00e0 degli Studi di Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulius","family":"Sudikas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kantonsspital Winterthur, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Katholing","sequence":"additional","affiliation":[{"name":"Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wallenhorst","sequence":"additional","affiliation":[{"name":"Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander T.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Martinez","sequence":"additional","affiliation":[{"name":"Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,3,27]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1683429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T18:36:13Z","timestamp":1558895773000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1683429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2019,5,26]]},"published-print":{"date-parts":[[2019,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1683429","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735413490.793565168","asserted-by":"object"}]},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]}}}