{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:15:13Z","timestamp":1791465313582,"version":"4.3.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"crossref","award":["project 9190"],"award-info":[{"award-number":["project 9190"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"crossref","award":["KL2 TR001426"],"award-info":[{"award-number":["KL2 TR001426"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n            Objective\u2003The accuracy of structural magnetic resonance imaging (MRI) to predict later cerebral palsy (CP) in newborns with perinatal brain injury is variable. Diffusion tensor imaging (DTI) and task-based functional MRI (fMRI) show promise as predictive tools. We hypothesized that infants who later developed CP would have reduced structural and functional connectivity as compared with those without CP.<\/jats:p><jats:p>\n            Study Design\u2003We performed DTI and fMRI using a passive motor task at 40 to 48 weeks' postmenstrual age in 12 infants with perinatal brain injury. CP was diagnosed at age 2 using a standardized examination.<\/jats:p><jats:p>\n            Results\u2003Five infants had CP at 2 years of age, and seven did not have CP. Tract-based spatial statistics showed a widespread reduction of fractional anisotropy (FA) in almost all white matter tracts in the CP group. Using the median FA value in the corticospinal tracts as a cutoff, FA was 100% sensitive and 86% specific to predict CP compared with a sensitivity of 60 to 80% and a specificity of 71% for structural MRI. During fMRI, the CP group had reduced functional connectivity from the right supplemental motor area as compared with the non-CP group.<\/jats:p><jats:p>\n            Conclusion\u2003DTI and fMRI obtained soon after birth are potential biomarkers to predict CP in newborns with perinatal brain injury.<\/jats:p>","DOI":"10.1055\/s-0039-1683874","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T20:05:33Z","timestamp":1553717133000},"page":"137-145","source":"Crossref","is-referenced-by-count":13,"title":["Neonatal Functional and Structural Connectivity Are Associated with Cerebral Palsy at Two Years of Age"],"prefix":"10.1055","volume":"37","author":[{"given":"Stephanie L.","family":"Merhar","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elveda","family":"Gozdas","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean A.","family":"Tkach","sequence":"additional","affiliation":[{"name":"Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal A.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth M.","family":"Kline-Fath","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"He","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott K.","family":"Holland","sequence":"additional","affiliation":[{"name":"Medpace Imaging Core Laboratory, Medpace Inc., Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,3,27]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1683874.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T18:31:20Z","timestamp":1579372280000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1683874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,1,18]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1683874","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]}}}