{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:25Z","timestamp":1790837065432,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            Objective\u2003To estimate sex-specific differences in late preterm outcomes and evaluate whether betamethasone modifies this association.<\/jats:p><jats:p>\n            Study Design\u2003We conducted a secondary analysis of a multicenter trial of women at risk for late preterm birth randomized to receive betamethasone or placebo. We included women who delivered at 34 to 37 weeks and excluded major fetal anomalies. The primary outcome was severe neonatal morbidity (mechanical ventilation, respiratory distress syndrome, bronchopulmonary dysplasia, sepsis, necrotizing enterocolitis, and intraventricular hemorrhage). Maternal characteristics were compared using chi-square test, t-test, or Mann\u2013Whitney U-test. Multivariable logistic regression estimated the association between sex and morbidity, and likelihood ratio testing assessed for effect modification by betamethasone.<\/jats:p><jats:p>\n            Results\u2003Of 2,831 women in the primary trial, 2,331 met the inclusion criteria: 1,236 delivered males and 1,095 delivered females. Betamethasone modified the association between sex and severe morbidity (p\u2009=\u20090.047). Among those who received betamethasone, male sex was associated with higher odds of severe morbidity (adjusted odds ratio: 1.95, 95% confidence interval: 1.25\u20133.05), compared with female sex. Among those who did not receive betamethasone, there was no significant association between sex and morbidity.<\/jats:p><jats:p>\n            Conclusion\u2003Male sex is a risk factor for adverse late preterm outcomes, including severe neonatal morbidity after betamethasone receipt.<\/jats:p>","DOI":"10.1055\/s-0039-1683886","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T23:22:27Z","timestamp":1555456947000},"page":"1223-1228","source":"Crossref","is-referenced-by-count":18,"title":["Sex-Specific Differences in Late Preterm Neonatal Outcomes"],"prefix":"10.1055","volume":"36","author":[{"given":"Ashley N.","family":"Battarbee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica V.","family":"Glover","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J.","family":"Vladutiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Gyamfi-Bannerman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Aliaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy A.","family":"Manuck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Boggess","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,4,16]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1683886.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T22:36:21Z","timestamp":1570055781000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1683886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,10,2]]},"published-print":{"date-parts":[[2019,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1683886","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]}}}