{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:37:10Z","timestamp":1775018230858,"version":"3.50.1"},"reference-count":85,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"04","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hypothesis of fetal origins to adult diseases proposes that metabolic chronic disorders, including cardiovascular diseases, diabetes, and hypertension originate in the developmental plasticity due to intrauterine insults. These processes involve an adaptative response by the fetus to changes in the environmental signals, which can promote the reset of hormones and of the metabolism to establish a \u201cthrifty phenotype\u201d. Metabolic alterations during intrauterine growth restriction can modify the fetal programming. The present nonsystematic review intended to summarize historical and current references that indicated that developmental origins of health and disease (DOHaD) occur as a consequence of altered maternal and fetal metabolic pathways. The purpose is to highlight the potential implications of growth factors and adipokines in \u201cdevelopmental programming\u201d, which could interfere in the development by controlling fetal growth patterns. These changes affect the structure and the functional capacity of various organs, including the brain, the kidneys, and the pancreas. These investigations may improve the approach to optimizing antenatal as well as perinatal care aimed to protect newborns against long-term chronic diseases.<\/jats:p>","DOI":"10.1055\/s-0039-1683904","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:16:36Z","timestamp":1554250596000},"page":"256-263","source":"Crossref","is-referenced-by-count":11,"title":["Hormonal Biomarkers for Evaluating the Impact of Fetal Growth Restriction on the Development of Chronic Adult Disease"],"prefix":"10.61622","volume":"41","author":[{"given":"Elizabeth Soares da Silva","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7290-9091","authenticated-orcid":false,"given":"Maria Dalva Barbosa Baker","family":"M\u00e9io","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elisabeth Lopes","family":"Moreira","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00404-017-4341-9","article-title":"Fetal growth restriction: current knowledge","volume":"295","author":"L M Nardozza","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(89)90710-1","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"2","author":"D J Barker","year":"1989","journal-title":"Lancet"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11154-005-6184-0","article-title":"Fetal origins of adult disease: a paediatric perspective","volume":"6","author":"H L Miles","year":"2005","journal-title":"Rev Endocr Metab Disord"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1440-1681.2012.05743.x","article-title":"Early origins of heart disease: low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy","volume":"39","author":"K C Wang","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-0031-1275516","article-title":"The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes","volume":"29","author":"S R Thorn","year":"2011","journal-title":"Semin Reprod Med"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1515\/jpm-2012-0020","article-title":"Fetal growth and developmental programming","volume":"41","author":"S Galjaard","year":"2013","journal-title":"J Perinat Med"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/ije\/dyt133","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. 1992","volume":"42","author":"C N Hales","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/GRF.0b013e31829cb9ca","article-title":"The obstetric origins of health for a lifetime","volume":"56","author":"D J Barker","year":"2013","journal-title":"Clin Obstet Gynecol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1017\/S2040174416000337","article-title":"Human fetal growth restriction: a cardiovascular journey through to adolescence","volume":"7","author":"A Sehgal","year":"2016","journal-title":"J Dev Orig Health Dis"},{"issue":"17","key":"ref10","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1113\/JP271745","article-title":"Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations","volume":"594","author":"J N Cheong","year":"2016","journal-title":"J Physiol"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3109\/03014460.2012.712717","article-title":"Human growth and chronic disease: a memorial to Jim Tanner","volume":"39","author":"D J Barker","year":"2012","journal-title":"Ann Hum Biol"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1017\/S2040174415001324","article-title":"The \u2018Developmental Origins\u2019 Hypothesis: relevance to the obstetrician and gynecologist","volume":"6","author":"A J Kermack","year":"2015","journal-title":"J Dev Orig Health Dis"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/ije\/dyi048","article-title":"Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years","volume":"34","author":"E Kajantie","year":"2005","journal-title":"Int J Epidemiol"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM197608122950701","article-title":"Obesity in young men after famine exposure in utero and early infancy","volume":"295","author":"G P Ravelli","year":"1976","journal-title":"N Engl J Med"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/ije\/dym126","article-title":"Cohort profile: the Dutch Hunger Winter families study","volume":"36","author":"L H Lumey","year":"2007","journal-title":"Int J Epidemiol"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.maturitas.2011.06.017","article-title":"Hungry in the womb: what are the consequences? Lessons from the Dutch famine","volume":"70","author":"T J Roseboom","year":"2011","journal-title":"Maturitas"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1210\/jc.2002-021380","article-title":"Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth","volume":"88","author":"E Kajantie","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/ije\/dyn012","article-title":"Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study","volume":"37","author":"E Kajantie","year":"2008","journal-title":"Int J Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1799S","DOI":"10.3945\/ajcn.110.000638","article-title":"Early growth and coronary heart disease and type 2 diabetes: findings from the Helsinki Birth Cohort Study (HBCS)","volume":"94","author":"J G Eriksson","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"08","key":"ref20","first-page":"935","article-title":"Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature","volume":"14","author":"C M Law","year":"1996","journal-title":"J Hypertens"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1053\/j.semperi.2007.11.005","article-title":"Adult sequelae of intrauterine growth restriction","volume":"32","author":"M G Ross","year":"2008","journal-title":"Semin Perinatol"},{"issue":"06","key":"ref22","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.3945\/ajcn.2008.27038","article-title":"Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study","volume":"89","author":"L H Lumey","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/eurheartj\/ehq448","article-title":"Estimating modifiable coronary heart disease risk in multiple regions of the world: the INTERHEART Modifiable Risk Score","volume":"32","author":"C McGorrian","year":"2011","journal-title":"Eur Heart J"},{"issue":"14","key":"ref25","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1161\/CIRCULATIONAHA.113.001470","article-title":"The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008","volume":"127","author":"G Danaei","year":"2013","journal-title":"Circulation"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2337\/dc11-0456","article-title":"Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts","volume":"35","author":"S A Norris","year":"2012","journal-title":"Diabetes Care"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1515\/JPEM.2010.23.3.215","article-title":"Intrauterine growth restriction as a potential risk factor for disease onset in adulthood","volume":"23","author":"A A Varvarigou","year":"2010","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MED.0b013e32834c800d","article-title":"Placental hormones and the control of maternal metabolism and fetal growth","volume":"18","author":"D Newbern","year":"2011","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3892\/br.2017.930","article-title":"Human placental growth hormone in normal and abnormal fetal growth","volume":"7","author":"A Velegrakis","year":"2017","journal-title":"Biomed Rep"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.yfrne.2014.05.007","article-title":"The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)","volume":"35","author":"A Wolfe","year":"2014","journal-title":"Front Neuroendocrinol"},{"issue":"08","key":"ref31","doi-asserted-by":"crossref","first-page":"e106037","DOI":"10.1371\/journal.pone.0106037","article-title":"Regulation of human trophoblast GLUT1 glucose transporter by insulin-like growth factor I (IGF-I)","volume":"9","author":"M U Baumann","year":"2014","journal-title":"PLoS One"},{"issue":"15","key":"ref32","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1113\/JP273330","article-title":"Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth","volume":"595","author":"A N Sferruzzi-Perri","year":"2017","journal-title":"J Physiol"},{"issue":"02","key":"ref33","first-page":"499","article-title":"Insulin-like growth factor-I is a marker for the nutritional state","volume":"13","author":"C P Hawkes","year":"2015","journal-title":"Pediatr Endocrinol Rev"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.earlhumdev.2010.05.002","article-title":"Describing hypoglycemia--definition or operational threshold?","volume":"86","author":"P J Rozance","year":"2010","journal-title":"Early Hum Dev"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/eurjhf\/hfq166","article-title":"Insulin-like growth factor axis (insulin-like growth factor-I\/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin","volume":"12","author":"S Watanabe","year":"2010","journal-title":"Eur J Heart Fail"},{"issue":"05","key":"ref36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1365-2265.2006.02632.x","article-title":"Leptin, insulin, insulin-like growth factors and their binding proteins in cord serum: insight into fetal growth and discordancy","volume":"65","author":"S Davidson","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jcmm.13369","article-title":"Leptin action in normal and pathological pregnancies","volume":"22","author":"A P\u00e9rez-P\u00e9rez","year":"2018","journal-title":"J Cell Mol Med"},{"issue":"06","key":"ref38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1515\/JPM.2009.122","article-title":"Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction","volume":"37","author":"M D Baker M\u00e9io","year":"2009","journal-title":"J Perinat Med"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/jpm.2010.136","article-title":"Placental volume and vascularization flow indices by 3D power Doppler US using VOCAL technique and correlation with IGF-1, free beta-hCG, PAPP-A, and uterine artery Doppler at 11-14 weeks of pregnancy","volume":"39","author":"A B Yigiter","year":"2011","journal-title":"J Perinat Med"},{"issue":"03","key":"ref40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1373\/clinchem.2007.095299","article-title":"Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry?","volume":"54","author":"C Chiesa","year":"2008","journal-title":"Clin Chem"},{"issue":"03","key":"ref41","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1017\/S204017441400021X","article-title":"Leptin levels at birth and infant growth: the EPOCH study","volume":"5","author":"J L Kaar","year":"2014","journal-title":"J Dev Orig Health Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.metabol.2017.11.006","article-title":"Adipose tissue and reproductive health","volume":"86","author":"H Mathew","year":"2018","journal-title":"Metabolism"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1113\/jphysiol.2008.167072","article-title":"The hungry fetus? Role of leptin as a nutritional signal before birth","volume":"587","author":"A J Forhead","year":"2009","journal-title":"J Physiol"},{"issue":"05","key":"ref44","doi-asserted-by":"crossref","first-page":"E335","DOI":"10.1152\/ajpendo.00312.2014","article-title":"Leptin in pregnancy and development: a contributor to adulthood disease?","volume":"308","author":"J F Briffa","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1055\/s-0036-1586109","article-title":"Role of Insulin Like Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants","volume":"33","author":"A Hellstr\u00f6m","year":"2016","journal-title":"Am J Perinatol"},{"issue":"02","key":"ref46","first-page":"131","article-title":"Intrauterine growth restriction: hungry for an answer","volume":"31","author":"S U Devaskar","year":"2016","journal-title":"Physiology (Bethesda)"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine growth restriction: antenatal and postnatal aspects","volume":"10","author":"D Sharma","year":"2016","journal-title":"Clin Med Insights Pediatr"},{"issue":"03","key":"ref48","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/GRF.0b013e31829e5b29","article-title":"Prenatal programming of insulin secretion in intrauterine growth restriction","volume":"56","author":"K L Gatford","year":"2013","journal-title":"Clin Obstet Gynecol"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.beem.2007.08.001","article-title":"Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance","volume":"22","author":"A G Dulloo","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"03","key":"ref50","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.ki.5002307","article-title":"Prenatal programming of nephron number and blood pressure","volume":"72","author":"M F Schreuder","year":"2007","journal-title":"Kidney Int"},{"issue":"02","key":"ref51","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/er.2013-1071","article-title":"Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications","volume":"35","author":"P Kamenick\u00fd","year":"2014","journal-title":"Endocr Rev"},{"issue":"02","key":"ref52","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1046\/j.1523-1755.2000.00225.x","article-title":"Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study","volume":"58","author":"R Ma\u00f1alich","year":"2000","journal-title":"Kidney Int"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1530\/JME-12-0025","article-title":"Role of leptin in the pancreatic \u03b2-cell: effects and signaling pathways","volume":"49","author":"L Marroqu\u00ed","year":"2012","journal-title":"J Mol Endocrinol"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/157339913804143225","article-title":"Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes","volume":"9","author":"Z Fu","year":"2013","journal-title":"Curr Diabetes Rev"},{"issue":"04","key":"ref55","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"S L Miller","year":"2016","journal-title":"J Physiol"},{"issue":"07","key":"ref56","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.bbi.2009.02.001","article-title":"Fetal origins of mental health: evidence and mechanisms","volume":"23","author":"W Schlotz","year":"2009","journal-title":"Brain Behav Immun"},{"issue":"03","key":"ref57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/uog.11112","article-title":"Neurodevelopmental delay in small babies at term: a systematic review","volume":"40","author":"T Arcangeli","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"02","key":"ref58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12020-015-0658-y","article-title":"Hypothalamic-autonomic control of energy homeostasis","volume":"50","author":"P Seoane-Collazo","year":"2015","journal-title":"Endocrine"},{"issue":"06","key":"ref59","doi-asserted-by":"crossref","first-page":"R938","DOI":"10.1152\/ajpregu.00045.2016","article-title":"Role of leptin in energy expenditure: the hypothalamic perspective","volume":"312","author":"R Pandit","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"01","key":"ref60","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.metabol.2014.08.004","article-title":"Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism","volume":"64","author":"H K Park","year":"2015","journal-title":"Metabolism"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jchemneu.2014.05.001","article-title":"The impact of leptin on perinatal development and psychopathology","author":"J C Valleau","year":"2014","journal-title":"J Chem Neuroanat"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2016.03.056","article-title":"The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity","volume":"325","author":"A H Dyer","year":"2016","journal-title":"Neuroscience"},{"issue":"03","key":"ref63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1053\/j.semperi.2010.02.005","article-title":"Consequences of intrauterine growth and early neonatal catch-up growth","volume":"34","author":"O Claris","year":"2010","journal-title":"Semin Perinatol"},{"issue":"12","key":"ref64","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1210\/jc.2010-0271","article-title":"Insulin-like growth factor-I in cord blood is predictive of catch-up growth in monozygotic twins with discordant growth","volume":"95","author":"B C Gohlke","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"04","key":"ref65","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/tpj.2014.4","article-title":"Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: an integrated analysis of metabolic and transcriptomic data","volume":"14","author":"A Stevens","year":"2014","journal-title":"Pharmacogenomics J"},{"issue":"05","key":"ref66","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1515\/jpem.2010.077","article-title":"Serum levels of adiponectin and leptin in children born small for gestational age: relation to insulin sensitivity parameters","volume":"23","author":"M Miras","year":"2010","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"11","key":"ref67","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1055\/s-0032-1321759","article-title":"Serum insulin-like growth factor I (IGF-I), IGF-binding proteins-1 and -3, and postnatal growth of late preterm infants","volume":"44","author":"V I Giapros","year":"2012","journal-title":"Horm Metab Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/pr.2014.164","article-title":"Early postnatal alteration of body composition in preterm and small-for-gestational-age infants: implications of catch-up fat","volume":"77","author":"T Okada","year":"2015","journal-title":"Pediatr Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"134758","DOI":"10.1155\/2012\/134758","article-title":"In utero programming of later adiposity: the role of fetal growth restriction","volume":"2012","author":"O Sarr","year":"2012","journal-title":"J Pregnancy"},{"issue":"08","key":"ref70","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1515\/jpem-2015-0463","article-title":"Ghrelin, insulin-like growth factor I and adipocytokines concentrations in born small for gestational age prepubertal children after the catch-up growth","volume":"29","author":"R Stawerska","year":"2016","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"07","key":"ref71","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/ijo.2014.24","article-title":"Height, adiposity and hormonal cardiovascular risk markers in childhood: how to partition the associations?","volume":"38","author":"J C Wells","year":"2014","journal-title":"Int J Obes"},{"issue":"05","key":"ref72","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00125-005-1724-4","article-title":"Dynamic change in adiposity from fetal to postnatal life is involved in the metabolic syndrome associated with reduced fetal growth","volume":"48","author":"D Jaquet","year":"2005","journal-title":"Diabetologia"},{"issue":"12","key":"ref73","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1210\/jc.2012-1716","article-title":"Health profile of young adults born preterm: negative effects of rapid weight gain in early life","volume":"97","author":"G F Kerkhof","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"03","key":"ref74","doi-asserted-by":"crossref","first-page":"e33084","DOI":"10.1371\/journal.pone.0033084","article-title":"Incremental effects of endocrine and metabolic biomarkers and abdominal obesity on cardiovascular mortality prediction","volume":"7","author":"H J Schneider","year":"2012","journal-title":"PLoS One"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2014.12.010","article-title":"Role of the kidney in the fetal programming of adult cardiovascular disease: an update","volume":"21","author":"R R Singh","year":"2015","journal-title":"Curr Opin Pharmacol"},{"issue":"06","key":"ref76","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2459\/JCM.0b013e328358c7c7","article-title":"The association of insulin-like growth factor-1 with severity of coronary artery disease","volume":"14","author":"G Yousefzadeh","year":"2013","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"01","key":"ref77","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000355387","article-title":"Maternal leptin predicts adiposity of the neonate","volume":"81","author":"J L Josefson","year":"2014","journal-title":"Horm Res Paediatr"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1542\/peds.111.6.1253","article-title":"International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001","volume":"111","author":"P A Lee","year":"2003","journal-title":"Pediatrics"},{"issue":"07","key":"ref79","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11883-014-0419-z","article-title":"Insulin resistance, diabetes, and cardiovascular risk","volume":"16","author":"F Paneni","year":"2014","journal-title":"Curr Atheroscler Rep"},{"issue":"01","key":"ref80","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/archdischild-2012-302510","article-title":"Catch-up growth in children born growth restricted to mothers with hypertensive disorders of pregnancy","volume":"98","author":"F Beukers","year":"2013","journal-title":"Arch Dis Child"},{"issue":"05","key":"ref81","first-page":"307","article-title":"Temporal changes in insulin-like growth factors I and II and in insulin-like growth factor binding proteins 1, 2, and 3 in human milk","volume":"69","author":"S R Milsom","year":"2008","journal-title":"Horm Res"},{"issue":"04","key":"ref82","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/MPG.0b013e3182062fcc","article-title":"Adiponectin, AFABP, and leptin in human breast milk during 12 months of lactation","volume":"52","author":"J Bronsky","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"02","key":"ref83","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bpobgyn.2014.08.004","article-title":"The offspring of the diabetic mother--short- and long-term implications","volume":"29","author":"D Mitanchez","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"04","key":"ref84","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00404-016-4178-7","article-title":"Implications of maternal conditions and pregnancy course on offspring's medical problems in adult life","volume":"294","author":"J von Ehr","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12889-016-2809-3","article-title":"Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)","volume":"16","author":"S K Berglund","year":"2016","journal-title":"BMC Public Health"},{"issue":"S 02","key":"ref86","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/j.placenta.2012.07.018","article-title":"The next generation of disease risk: are the effects of prenatal nutrition transmitted across generations? Evidence from animal and human studies","volume":"33","author":"T J Roseboom","year":"2012","journal-title":"Placenta"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/hormonal-biomarkers-for-evaluating-the-impact-of-fetal-growth-restriction-on-the-development-of-chronic-adult-disease\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1683904.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:56:14Z","timestamp":1721336174000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/hormonal-biomarkers-for-evaluating-the-impact-of-fetal-growth-restriction-on-the-development-of-chronic-adult-disease\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":85,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,5,2]]},"published-print":{"date-parts":[[2019,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1683904","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}