{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:09:43Z","timestamp":1776481783966,"version":"3.51.2"},"reference-count":47,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"05","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Objective\u2003To evaluate and compare the prevalence of structural congenital anomalies (CAs) according to maternal body mass index (BMI).<\/jats:p><jats:p>Methods\u2003The present cross-sectional study involved pregnant women with fetuses diagnosed with structural CAs through morphological ultrasonography between November 2014 and January 2016. The nutritional status of the pregnant women was classified according to the gross value of the body mass index. The pregnant women were categorized into four groups: low weight, adequate weight, overweight, and obesity. Statistical analysis was performed using Stata\/SE version 12.0 (Stata Corporation, College Station, TX), with values of p\u2009\u2264\u20090.05 considered statistically significant.<\/jats:p><jats:p>Results\u2003A total of 223 pregnant women had fetuses diagnosed with CAs. The prevalence of structural CAs in pregnant women with low weight was of 20.18%, of 43.50% in pregnant women with adequate weight, of 22.87% in pregnant women with overweight, and of 13.45% in pregnant women with obesity. The prevalence of central nervous system (CNS) anomalies and of genitourinary system anomalies was high for the four groups of pregnant women. A positive association was observed between multiple anomalies in pregnant women with adequate weight (prevalence ratio [PR]\u2009=\u20091.65; p\u2009\u2264\u20090.004) and between anomalies of the lymphatic system in obese pregnant women (PR\u2009=\u20094.04, p\u2009\u2264\u20090.000).<\/jats:p><jats:p>Conclusion\u2003The prevalence of CNS and genitourinary system anomalies was high in all of the BMI categories. Obese pregnancies were associated with lymphatic system anomalies. Therefore, screening and identification of the risk factors for CAs are important, regardless of the maternal BMI. Our findings reinforce the importance of discussing with pregnant women maternal nutrition and its effect on fetal development and on neonatal outcome.<\/jats:p>","DOI":"10.1055\/s-0039-1683971","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T22:53:02Z","timestamp":1554763982000},"page":"280-290","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and Association of Congenital Anomalies According to the Maternal Body Mass Index: Cross-Sectional Study"],"prefix":"10.61622","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0755-0753","authenticated-orcid":false,"given":"Carolina Le\u00e3o de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Obstetrics and Gynecology, Hospital das Cl\u00ednicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Rodrigues","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Obstetrics and Gynecology, Hospital das Cl\u00ednicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia Cruz e","family":"Melo","sequence":"additional","affiliation":[{"name":"Paulista Medical School, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar Naves do","family":"Amaral","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Obstetrics and Gynecology, Hospital das Cl\u00ednicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"issue":"S 03","key":"ref1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1742-4755-11-S3-S3","article-title":"Preconception care: nutritional risks and interventions","volume":"11","author":"S V Dean","year":"2014","journal-title":"Reprod Health"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1590\/S0104-11692012000300006","article-title":"Nutritional status and weight gain in pregnant women","volume":"20","author":"A P Sato","year":"2012","journal-title":"Rev Lat Am Enfermagem"},{"issue":"04","key":"ref3","first-page":"170","article-title":"The impact of maternal obesity on maternal and fetal health","volume":"1","author":"M A Leddy","year":"2008","journal-title":"Rev Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/epirev\/mxq001","article-title":"Maternal nutrition and birth outcomes","volume":"32","author":"K Abu-Saad","year":"2010","journal-title":"Epidemiol Rev"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40618-014-0168-4","article-title":"Impact of maternal under nutrition on obstetric outcomes","volume":"38","author":"S Triunfo","year":"2015","journal-title":"J Endocrinol Invest"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000350170","article-title":"Impact of maternal obesity on fetal health","volume":"34","author":"K Tenenbaum-Gavish","year":"2013","journal-title":"Fetal Diagn Ther"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ajog.2007.03.027","article-title":"Maternal obesity and risk of stillbirth: a metaanalysis","volume":"197","author":"S Y Chu","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1479-828X.2008.00860.x","article-title":"Maternal obesity and pregnancy complications: a review","volume":"48","author":"J Ramachenderan","year":"2008","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"01","key":"ref9","first-page":"168","article-title":"Relationship between sociodemographics, dietary intake, and physical activity with gestational weight gain among pregnant women in Rafsanjan City, Iran","volume":"33","author":"F Ebrahimi","year":"2015","journal-title":"J Health Popul Nutr"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/j.sempedsurg.2015.09.004","article-title":"Congenital anomalies in the context of global surgery","volume":"25","author":"N A Sitkin","year":"2016","journal-title":"Semin Pediatr Surg"},{"issue":"S 01","key":"ref12","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1111\/nure.12058","article-title":"Prepregnancy obesity and the risk of birth defects: an update","volume":"71","author":"A Correa","year":"2013","journal-title":"Nutr Rev"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000343219","article-title":"Maternal obesity and detection rate of fetal structural anomalies","volume":"33","author":"E Hildebrand","year":"2013","journal-title":"Fetal Diagn Ther"},{"issue":"S 02","key":"ref14","doi-asserted-by":"crossref","first-page":"1606S","DOI":"10.1093\/jn\/133.5.1606S","article-title":"Nutritional interventions during pregnancy for the prevention or treatment of maternal morbidity and preterm delivery: an overview of randomized controlled trials","volume":"133","author":"J Villar","year":"2003","journal-title":"J Nutr"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00467-016-3543-x","article-title":"Maternal obesity is associated with congenital anomalies of the kidney and urinary tract in offspring","volume":"32","author":"I Macumber","year":"2017","journal-title":"Pediatr Nephrol"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bdra.20620","article-title":"Maternal obesity and morbid obesity: the risk for birth defects in the offspring","volume":"88","author":"M I Blomberg","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2009.113","article-title":"Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis","volume":"301","author":"K J Stothard","year":"2009","journal-title":"JAMA"},{"key":"ref18","first-page":"184","article-title":"European recommendations for primary prevention of congenital anomalies: a joined effort of EUROCAT and EUROPLAN projects to facilitate inclusion of this topic in the National Rare Disease Plans","volume":"18","author":"D Taruscio","year":"2015","journal-title":"Public Health Genomics"},{"issue":"12","key":"ref19","first-page":"1429","article-title":"[Proposal of a new standard for the nutritional assessment of pregnant women]","volume":"125","author":"E Atalah","year":"1997","journal-title":"Rev Med Chil"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"162","DOI":"10.5455\/2320-1770.ijrcog20140332","article-title":"Surveillance of congenital malformations and their possible risk factors in a teaching hospital in Punjab","volume":"3","author":"S Marwah","year":"2014","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejmhg.2016.04.001","article-title":"Risk factors for congenital anomalies in high risk pregnant women: a large study from South India","volume":"18","author":"T Sunitha","year":"2017","journal-title":"Egypt J Med Hum Genet"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.18203\/2320-6012.ijrms20161758","article-title":"A study of incidence of congenital anomalies in newborn: a hospital based study","volume":"4","author":"N Prashar","year":"2016","journal-title":"Int J Res Med Sci."},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"E741","DOI":"10.3390\/nu8110741","article-title":"Nutrition, one-carbon metabolism and neural tube: a review","volume":"8","author":"K Li","year":"2016","journal-title":"Nutrients"},{"issue":"06","key":"ref25","first-page":"1104","article-title":"A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family","volume":"26","author":"N Singh","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"339.e1","DOI":"10.1016\/j.ajog.2009.07.002","article-title":"A systematic review of outcomes of maternal weight gain according to the Institute of Medicine recommendations: birthweight, fetal growth, and postpartum weight retention","volume":"201","author":"A M Siega-Riz","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2393-10-56","article-title":"The risk of adverse pregnancy outcomes in women who are overweight or obese","volume":"10","author":"C Athukorala","year":"2010","journal-title":"BMC Pregnancy Childbirth"},{"issue":"09","key":"ref28","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/ijo.2010.66","article-title":"Maternal body mass index and congenital anomaly risk: a cohort study","volume":"34","author":"J Rankin","year":"2010","journal-title":"Int J Obes"},{"issue":"08","key":"ref29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/obr.12288","article-title":"Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews","volume":"16","author":"J Marchi","year":"2015","journal-title":"Obes Rev"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0250-474X.51941","article-title":"Drug use in pregnancy; a point to ponder!","volume":"71","author":"P Sachdeva","year":"2009","journal-title":"Indian J Pharm Sci"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jogc.2015.10.009","article-title":"Beyond alcohol and tobacco smoke: Are we doing enough to reduce fetal toxicant exposure?","volume":"38","author":"E Crighton","year":"2016","journal-title":"J Obstet Gynaecol Can"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00381-011-1607-6","article-title":"Head circumference at birth and exposure to tobacco, alcohol and illegal drugs during early pregnancy","volume":"28","author":"J A Ortega-Garc\u00eda","year":"2012","journal-title":"Childs Nerv Syst"},{"key":"ref33","first-page":"226","article-title":"[Congenital defects: maternal and perinatal features]","volume":"53","author":"A Calone","year":"2009","journal-title":"Rev AMRIGS."},{"key":"ref34","first-page":"9","article-title":"[Epidemiologic factors correlated to the risk for fetal death: integrative review]","volume":"23","author":"R MM Silva","year":"2016","journal-title":"Arq Ci\u00eanc Sa\u00fade."},{"issue":"05","key":"ref35","first-page":"541","article-title":"[Validation of ultrasound diagnosis of fetal anomalies at a reference center in Pernambuco]","volume":"55","author":"C Noronha Neto","year":"2009","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/wsbm.1212","article-title":"Lower urinary tract development and disease","volume":"5","author":"H M Rasouly","year":"2013","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/j.1471-0528.2012.03462.x","article-title":"Impact of maternal body mass index on the antenatal detection of congenital anomalies","volume":"119","author":"K E Best","year":"2012","journal-title":"BJOG"},{"issue":"08","key":"ref38","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.7863\/jum.2009.28.8.1025","article-title":"Maternal obesity limits the ultrasound evaluation of fetal anatomy","volume":"28","author":"J S Dashe","year":"2009","journal-title":"J Ultrasound Med"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/jcm3030795","article-title":"Limitations of aneuploidy and anomaly detection in the obese patient","volume":"3","author":"P Zozzaro-Smith","year":"2014","journal-title":"J Clin Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"j2563","DOI":"10.1136\/bmj.j2563","article-title":"Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons","volume":"357","author":"M Persson","year":"2017","journal-title":"BMJ"},{"issue":"02","key":"ref41","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/0194599814559190","article-title":"Prognostic value of a simplified anatomically based nomenclature for fetal nuchal lymphatic anomalies","volume":"152","author":"B Longstreet","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"21","key":"ref42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.22490\/24629448.1838","article-title":"Diagn\u00f3stico pr\u00e9natal: retrospectiva","volume":"12","author":"L M Bernal","year":"2014","journal-title":"Nova"},{"issue":"05","key":"ref43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cga.12233","article-title":"Nutritional role of folate","volume":"57","author":"S Ebara","year":"2017","journal-title":"Congenit Anom (Kyoto)"},{"issue":"03","key":"ref44","first-page":"107","article-title":"[Obesity and pregnancy]","volume":"31","author":"R Mattar","year":"2009","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"05","key":"ref45","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/bdrb.21120","article-title":"TGF\u03b2 and Wnt in cardiac outflow tract defects in offspring of diabetic pregnancies","volume":"101","author":"Z Zhao","year":"2014","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s40064-016-2180-y","article-title":"Maternal diabetes impairs oxidative and inflammatory response in murine placenta","volume":"5","author":"M I Saad","year":"2016","journal-title":"Springerplus"},{"issue":"04","key":"ref47","first-page":"857","article-title":"Management of diabetes mellitus complicating pregnancy","volume":"102","author":"S G Gabbe","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref48","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/ije\/dyv107","article-title":"Prevalence of congenital heart disease and its related risk indicators among 90,796 Chinese infants aged less than 6 months in Tianjin","volume":"44","author":"X Liu","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"e000601","DOI":"10.1136\/bmjopen-2011-000601","article-title":"Pre-pregnancy body mass index and the risk of adverse outcome in type 1 diabetic pregnancies: a population-based cohort study","volume":"2","author":"M Persson","year":"2012","journal-title":"BMJ Open"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/prevalence-and-association-of-congenital-anomalies-according-to-the-maternal-body-mass-index-cross-sectional-study\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1683971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:54:24Z","timestamp":1721336064000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/prevalence-and-association-of-congenital-anomalies-according-to-the-maternal-body-mass-index-cross-sectional-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":47,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2019,6,10]]},"published-print":{"date-parts":[[2019,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1683971","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]}}}