{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:28:58Z","timestamp":1773430138363,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":129,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg J"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            Background\u2003Peritoneal adhesions reoccur in up to 100% of cases, possibly causing complications like pain, secondary female infertility, and small bowel obstruction. The latter has a mortality rate of up to 15% during hospitalization. This study investigates if recurrence of peritoneal adhesions can be prevented by prophylactic use of the starch-based medical device 4DryField.<\/jats:p><jats:p>\n            Methods\u2003The course of 40 patients with surgery for intestinal obstruction and, partially, second intervention was analyzed. In both operations, adhesion severity and extent were scored 0 (no adhesions) to III (massive\/dense and vascular adhesions) and 0 (no adhesions) to III (extensive, covering more than approximately 25\u2009\u00d7\u200925 cm), respectively. To prevent recurrence of adhesions all patients were treated with 4DryField gel (60 mL saline solution per 5\u2009g powder), evenly distributed on the whole impaired intestine (including anastomoses) before abdominal closure. Follow-up was up to 1.5 years in a 3 to 6 months' interval.<\/jats:p><jats:p>\n            Results\u2003Eight patients had relaparotomies on postoperative days 1 to 155. In the first operation, median adhesion severity score was III, median adhesion extent II. In redo-surgeries, significantly lower scores were detected (median adhesion severity: 0, p\u2009=\u20090.0003; median adhesion extent: 0, p\u2009=\u20090.0009). No adverse events related to the product were observed. One patient had later redo-surgery in another hospital due to recurrence of adhesions, one patient suffered from flatulence. All other patients were free of adhesion-related symptoms during follow-up.<\/jats:p><jats:p>\n            Conclusion\u2003Based on the high severity of diseases and the significant reduction of adhesion severity and extent in redo-surgeries, 4DryField gel is a promising adjunct for adhesion prevention in bowel surgery. The favorable results should be confirmed in prospective randomized trials.<\/jats:p>","DOI":"10.1055\/s-0039-1687857","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T18:49:48Z","timestamp":1557514188000},"page":"e28-e34","source":"Crossref","is-referenced-by-count":20,"title":["Significant Adhesion Reduction with 4DryField PH after Release of Adhesive Small Bowel Obstruction"],"prefix":"10.1055","volume":"05","author":[{"given":"Mouhannad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Aller-Weser-Klinik, Verden (Aller), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Crescenti","sequence":"additional","affiliation":[{"name":"Aller-Weser-Klinik, Verden (Aller), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,5,10]]},"container-title":["The Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1687857.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T18:49:48Z","timestamp":1557514188000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1687857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,1,8]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1687857","relation":{},"ISSN":["2378-5128","2378-5136"],"issn-type":[{"value":"2378-5128","type":"print"},{"value":"2378-5136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}