{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:56:09Z","timestamp":1787583369665,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Introduction\u2003Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature.<\/jats:p>\n Objective\u2003To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx.<\/jats:p>\n Methods\u2003This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression.<\/jats:p>\n Results\u2003A total of 107 patients with a mean age of 59.8 years (range 19\u201381) were included in this study. Stages III and IV were associated with decreased DFS (p\u2009=\u20090.02) and OS (p\u2009=\u20090.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p\u2009=\u20090.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p\u2009=\u20090.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p\u2009=\u20090.04).<\/jats:p>\n Conclusion\u2003Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.<\/jats:p>","DOI":"10.1055\/s-0039-1687909","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T20:07:57Z","timestamp":1559074077000},"page":"e299-e304","source":"Crossref","is-referenced-by-count":6,"title":["Laryngeal Cancer Attributable Factors and the Influence on Survival Rates: A Single Brazilian Institution Experience"],"prefix":"10.1055","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-5178","authenticated-orcid":false,"given":"Lara Maria Alencar","family":"Ramos Innocentini","sequence":"additional","affiliation":[{"name":"Dentistry and Stomatology Division, Ophthalmology, Otolaryngology and Head and Neck Surgery Department, Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisson Henrique","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculdade de Odontologia da Universidade de Franca, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Assirati","family":"Casemiro","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Universidade de Franca, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Carrijo","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculdade de Odontologia da Universidade de Franca, Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Cristina","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Dentistry and Stomatology Division, Ophthalmology, Otolaryngology and Head and Neck Surgery Department, Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilton Marcos Alves","family":"Ricz","sequence":"additional","affiliation":[{"name":"Ophthalmology, Otolaryngology and Head and Neck Surgery Department, Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Dorigan de","family":"Macedo","sequence":"additional","affiliation":[{"name":"Dentistry and Stomatology Division, Ophthalmology, Otolaryngology and Head and Neck Surgery Department, Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,5,28]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1687909.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T18:31:12Z","timestamp":1564165872000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1687909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,7,26]]},"published-print":{"date-parts":[[2019,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1687909","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]}}}